A randomized controlled trial to assess the effectiveness and safety of acupuncture for overactive bladder: a study in Hong Kong population.
A randomized controlled trial to assess the effectiveness and safety of acupuncture for overactive bladder: a study in Hong Kong population.
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DOI：
10.1186/s13020-020-00388-w
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发表时间：
2020
期刊：
影响因子：
4.9
通讯作者：
Guo Y
中科院分区：
文献类型：
--
作者：
Lin ZX;Chan NHT;Kwan YK;Chan YT;Zhang H;Tam KS;Lai MK;Lee CK;Ngan K;Tsoi SYY;Lau YW;Xian YF;Ching J;Guo Y
约有15%的香港人口被发现患有膀胱过度活动症（OAB），但目前可用的治疗方法，如药物治疗，行为治疗和物理治疗并不理想。以往的研究表明，针灸可能对OAB有很好的效果，但研究设计的一些限制使证据值得怀疑。本研究旨在评估针灸治疗OAB患者的有效性和安全性。入组了100例OAB患者。将患者随机分为主动针刺组和假针刺组，每周2次，连续8周，并在针刺干预完成后12周进行随访。主要结局评估是3天排尿日记，记录基线、8周干预结束时和针刺干预后12周的日间和夜间排尿频率和症状。次要结果包括尿神经生长因子水平、尿失禁影响问卷（IIQ-7）和泌尿生殖道窘迫量表（UDI-6）以及膀胱过度活动症状评分（OABSS）。治疗16个疗程后，与治疗前比较，针刺组和假针刺组的尿急性尿失禁（UUI）发生率、日间和夜间尿频以及IIQ-7、UDI-6和OABSS评分均显著降低。而且，治疗效果至少可以持续3个月。然而，无显着差异的频率UUI和白天排尿频率之间的积极和假针刺组。另一方面，在控制基线夜间排尿频率后，主动针刺组在治疗和随访期间的夜间排尿频率下降比假对照组更显著。本实验用ELISA法未能检测到尿中NGF水平。这项研究表明针灸对改善OAB症状有有益的作用。主动针刺和假针刺治疗均能改善急迫性尿失禁的频率、白天和夜间的尿频症状，但仅发现轻微的不良反应，本项目无法确定针刺治疗OAB的特异性疗效。试验注册中国临床试验注册中心，ChiCTR-INR-16010048。于2016年11月29日注册。
Around 15% of the Hong Kong population was found to suffer from overactive bladder (OAB), but the current available treatments, such as medication, behavioral therapy and physical therapy are unsatisfactory. Previous studies have suggested that acupuncture may have promising effect for OAB, but some limitations on the study design render the evidence questionable. This study aimed to evaluate the effectiveness and safety of acupuncture treatment for patients with OAB in Hong Kong. One hundred patients with OAB were enrolled. The patients were randomized to receive either active acupuncture or sham needle intervention twice a week for 8 consecutive weeks, and had a follow-up consultation 12 weeks after the completion of acupuncture intervention. The primary outcome assessment was the 3-Day Voiding Diary, which records daytime and night-time urinary frequency and symptoms, at the baseline, the end of the 8-week intervention and 12 weeks after acupuncture intervention. Secondary outcomes included Urine NGF level, Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6), as well as Overactive Bladder Symptom Score (OABSS). After 16 sessions of treatment, when compared with the baseline, both active and sham acupuncture significantly reduced the frequency of urgency urinary incontinence (UUI), daytime and night-time urinary frequency as well as the scores of IIQ-7, UDI-6 and OABSS. Moreover, the treatment effects could last for at least 3 months. However, no significant difference in frequency of UUI and daytime urinary frequency was found between the active and sham acupuncture groups. On the other hand, the night-time urinary frequency decreased more significantly during the treatment and follow-up in the active acupuncture group than in the sham control group after controlling baseline night-time urinary frequency. Urine NGF level could not be detected by ELISA method in our experiments. This study suggests a beneficial effect of acupuncture on improving OAB symptoms. Both active and sham acupuncture treatment were able to improve the symptoms of frequency of urgency urinary incontinence, and the daytime and night-time urinary frequency, while only mild adverse effects were found. This project was unable to establish the specific effect of acupuncture for OAB. Trial registration Chinese Clinical Trial Registry, ChiCTR-INR-16010048. Registered on 29 Nov 2016.
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DOI：
10.1155/2013/708251
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Moroz A;Freed B;Tiedemann L;Bang H;Howell M;Park JJ
通讯作者：
Park JJ
影响因子：
2.1
作者：
Mckellar, Keneta;Bellin, Eran;Abraham, Nitya
通讯作者：
Abraham, Nitya
DOI：
10.1016/j.cct.2003.10.016
发表时间：
2004-04-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Bang, HJ;Ni, LY;Davis, CE
通讯作者：
Davis, CE
影响因子：
1.6
作者：
Leron, Elad;Weintraub, Adi Y;Schwarzman, Polina
通讯作者：
Schwarzman, Polina
影响因子：
3.2
作者：
Siu, Judy Yuen-man
通讯作者：
Siu, Judy Yuen-man