Chapter seven--Cancer treatment with gene therapy and radiation therapy.
Chapter seven--Cancer treatment with gene therapy and radiation therapy.
复制标题
DOI：
10.1016/b978-0-12-398342-8.00007-0
复制
发表时间：
2012
影响因子：
--
通讯作者：
Buchsbaum, Donald J.
中科院分区：
文献类型：
--
作者：
Kaliberov, Sergey A.;Buchsbaum, Donald J.
近年来，放射治疗方法有了显着的发展，导致了更有效的局部肿瘤控制，而对周围正常组织的毒性可以忽略不计。然而，放射治疗后的局部复发和远处转移往往是由于放射抵抗的形成，通过细胞周期的解调、细胞的凋亡和DNA损伤修复机制的抑制而形成的。在过去的十年里，放射治疗和基因治疗相结合的方法已经取得了广泛的进展，以克服肿瘤细胞对辐射的抵抗力。本文就放射治疗与基因治疗相结合的实验性肿瘤治疗研究成果进行综述。
Radiation therapy methods have evolved remarkably in recent years which have resulted in more effective local tumor control with negligible toxicity of surrounding normal tissues. However, local recurrence and distant metastasis often occur following radiation therapy mostly due to the development of radioresistance through the deregulation of the cell cycle, apoptosis, and inhibition of DNA damage repair mechanisms. Over the last decade, extensive progress in radiotherapy and gene therapy combinatorial approaches has been achieved to overcome resistance of tumor cells to radiation. In this review, we summarize the results from experimental cancer therapy studies on the combination of radiation therapy and gene therapy.