Mode of action of OB protein (leptin) on feeding
Mode of action of OB protein (leptin) on feeding
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DOI：
10.1152/ajpregu.1998.275.1.r174
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发表时间：
1998-07-01
影响因子：
2.8
通讯作者：
Plata-Salamán, CR
中科院分区：
文献类型：
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作者：
Flynn, MC;Scott, TR;Plata-Salamán, CR
OB蛋白（瘦素）减少各种物种的食物摄入量。在这里，我们研究了脑室内注射重组鼠OB蛋白对Wistar大鼠自由进食时的摄食量和膳食参数的影响。脑室内注射OB蛋白（0.56-3.5 μ g/只）以剂量依赖性方式减少摄食。膳食参数的计算机分析表明，OB蛋白（3.5微克/大鼠，n = 10）减少夜间膳食量的42%，而用餐频率和用餐时间不受影响。对夜间的衍生分析还表明，OB蛋白降低了30%的进食率（餐量/餐时），而饱腹感比（餐间间隔/餐量）增加了100%。在白天和每日总时间段观察到相似的曲线。侧脑室注射热灭活OB蛋白（3.5 μ g/大鼠，n = 10）对任何膳食参数均无影响。结果表明，脑室内施用的OB蛋白通过特定的膳食量减少来抑制进食。
OB protein (leptin) decreases food intake in a variety of species. Here we investigated the effects of the intracerebroventricular administration of recombinant murine OB protein on food consumption and meal parameters in Wistar rats maintained ad libitum. The intracerebroventricular administration of OB protein (0.56-3.5 mu g/rat) decreased feeding in a dose-dependent manner. Computer analysis of meal parameters demonstrated that OB protein (3.5 mu g/rat, n = 10) decreased nighttime meal size by 42%, whereas meal frequency and meal duration were unaffected. Derived analyses for the nighttime also showed that OB protein decreased the feeding rate (meal size/meal duration) by 30%, whereas the satiety ratio (intermeal intervals/meal size) increased by 100%. A similar profile was observed during the daytime and total daily periods. The intracerebroventricular administration of heat-inactivated OB protein (3.5 mu g/rat, n = 10) had no effect on any meal parameter. The results show that OB protein administered intracerebroventricularly inhibits feeding through a specific reduction of meal size.