Selective cation movement across lipid bilayers containing brevetoxin B
Selective cation movement across lipid bilayers containing brevetoxin B
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DOI：
10.1002/anie.199607571
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发表时间：
1996-04-19
期刊：
影响因子：
--
通讯作者：
Nakanishi, K
中科院分区：
文献类型：
--
作者：
Matile, S;Nakanishi, K
脂双层中的短链藻毒素 B 形成了一个类似于离子通道的组件，这是从荧光标记的短链藻毒素 B 衍生物 1 的研究中得出的结论。短链藻毒素 B 促进特定阳离子跨膜运动的发现（见下图）揭示了除了之前观察到的神经元钠通道激活之外，其生物活性的第二个可能的方面。
An assembly resembling an ion channel is formed by brevetoxin B in lipid bilayers—this was the conclusion drawn from studies with the fluorescence‐labeled brevetoxin B derivative 1. The finding that brevetoxin B promotes specific cation movements across membranes (see the schematic representation below) reveals a second possible facet of its bioactivity besides the previously observed activation of neuronal sodium channels.