Inhibition of nitric oxide synthases abrogates pregnancy-induced uterine vascular expansive remodeling.
Inhibition of nitric oxide synthases abrogates pregnancy-induced uterine vascular expansive remodeling.
复制标题
抑制一氧化氮合酶可消除妊娠引起的子宫血管扩张重塑。
DOI：
10.1159/000200963
复制
发表时间：
2009
影响因子：
1.7
通讯作者：
Mandala,Maurizio
中科院分区：
文献类型：
--
作者：
Osol,George;Barron,Carolyn;Gokina,Natalia;Mandala,Maurizio
背景/目的：这是本研究的目的，以测试的假设，高血压和/或抑制一氧化氮（NO）脱氢酶改变子宫血管remodelingduring pregnancy.Methods：使用模型的高血压（NO synthase inhibition withL-NAME）在非妊娠和妊娠大鼠，进行了比较与年龄匹配的控制，以及与动物接受肼苯哒嗪沿着与L-NAME，以保持normotension在NO synthase抑制的存在。周向和轴向重塑的大（主子宫，MUA）和小（子宫前肌层桡动脉）arteries进行了量化和compared.Results：L-NAME治疗防止扩张性周向重塑的MUA; cotreatment与肼苯哒嗪是没有效果。在妊娠高血压动物中，较小的子宫前肌层桡动脉的周向重塑也显著减弱，而接受肼苯哒嗪和L-NAME的大鼠子宫前肌层桡动脉的直径为中等。无论是高血压，也没有NO合成酶抑制有任何影响的实质性（200-300%）轴向增长的MUA或premyometrial桡arteries.Conclusion：NO起着重要作用，促进妊娠引起的扩张性重构的子宫循环，特别是在较大的动脉。肼苯哒嗪对扩张性周向重塑的一些有益作用在较小的桡动脉血管中观察到，这些可能与其预防全身性高血压和/或对动脉壁的局部作用有关。无论是NO合酶抑制或高血压对动脉纵向生长有任何影响。
Background/Aims:It was the aim of this study to test the hypothesis that hypertension and/or inhibition of nitric oxide (NO) synthases alters uterine vascular remodeling during pregnancy.Methods:Using a model of hypertension (NO synthase inhibition withL-NAME) in nonpregnant and pregnant rats, comparisons were made with age-matched controls, as well as with animals receiving hydralazine along withL-NAME to maintain normotension in the presence of NO synthase inhibition. Circumferential and axial remodeling of large (main uterine, MUA) and small (premyometrial radial) arteries were quantified and compared.Results:L-NAME treatment prevented expansive circumferential remodeling of the MUA; cotreatment with hydralazine was without effect. Circumferential remodeling of smaller premyometrial radial arteries was also significantly attenuated in hypertensive pregnant animals, while premyometrial radial arteries from rats receiving hydralazine withL-NAME were of intermediate diameter. Neither hypertension nor NO synthase inhibition had any effect on the substantial (200–300%) axial growth of MUA or premyometrial radial arteries.Conclusion:NO plays a major role in facilitating pregnancy-induced expansive remodeling in the uterine circulation, particularly in larger arteries. Some beneficial effects of hydralazine on expansive circumferential remodeling were noted in smaller radial vessels, and these may be linked to its prevention of systemic hypertension and/or to local effects on the arterial wall. Neither NO synthase inhibition nor hypertension had any effect on arterial longitudinal growth.