Sex distinctiveness in effective genotype.
Sex distinctiveness in effective genotype.
复制标题
有效基因型的性别独特性。
DOI：
10.1007/0-306-47138-8_13
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
McClearn,GE
中科院分区：
文献类型：
--
作者：
McClearn,GE
酒精相关问题的发生率和流行率在性别之间存在差异，这是酒精研究的一个中心特征。这些差异将不可避免地受到越来越多的关注，因为越来越明显的是，研究与健康有关的过程中的性别差异既有利于公平，也有利于良好的科学。由于几个原因，遗传学方法有望为阐明性别差异提供强有力的工具。首先，性别的决定取决于遗传机制。此外，有大量的文献表明遗传与各种酒精相关过程的相关性。此外，有证据表明，男性和女性在酗酒方面的遗传影响存在重大差异。重要的是要认识到，遗传对性别特异性的影响可能通过几种不同的机制发挥作用，具有相当不同的含义。本章的目的是提供一个初步的描述这些不同的遗传途径的性别差异。
The difference between sexes in incidence and prevalence of alcohol-related problems is a central feature of alcohol research. It is inevitable that these differences will receive escalating attention as it becomes increasingly apparent that the interests of both equity and good science are served by the study of sex differences in health-related processes. For several reasons, genetic methods promise to offer powerful tools for the elucidation of sex differences. In the first place, the determination of sex depends on a genetic mechanism. Furthermore, there is an abundant literature showing the relevance of heredity to a broad variety of alcohol-related processes. Moreover, there is evidence of major differences in genetic influences in males and females in respect to alcoholism specifically. It is important to appreciate that genetic influence on sex distinctiveness may operate through several different mechanisms, with quite different implications. The purpose of this chapter is to provide an elementary description of these different genetic routes to sex differences.
遗传学、系统和酒精
影响因子：
2.6
作者：
G. Mcclearn
通讯作者：
G. Mcclearn