BASKET-LIKE INTERNEURONS IN LAYER-II OF THE ENTORHINAL CORTEX EXHIBIT A POWERFUL NMDA-MEDIATED SYNAPTIC EXCITATION
BASKET-LIKE INTERNEURONS IN LAYER-II OF THE ENTORHINAL CORTEX EXHIBIT A POWERFUL NMDA-MEDIATED SYNAPTIC EXCITATION
复制标题
DOI：
10.1016/0304-3940(93)90341-h
复制
发表时间：
1993-01-04
影响因子：
2.5
通讯作者：
BUHL, EH
中科院分区：
文献类型：
--
作者：
JONES, RSG;BUHL, EH
内嗅皮层（EC）第二层的棘状星状神经元为齿状回提供穿通通路输入。以往的研究表明，这些神经元的突触反应主要是由GABA能抑制。本研究描述了细胞内记录从'快速尖峰' interneurons在第二层，这可能是突触抑制的基础。荧光黄填充的快速尖峰细胞显示神经元与广泛的轴突树枝状形成篮状复合物周围的第二层未标记的细胞。突触激活的快速尖峰细胞引起长时间的兴奋，这主要是由NMDA受体介导的。还可检测到快速AMPA/红藻氨酸EPSP。这些神经元具有形态和生理特性，这使得它们非常适合于对第二层到齿状回的传出输出施加广泛的抑制控制。
Spiny stellate neurones of layer II of the entorhinal cortex (EC) provide the perforant path input to the dentate gyrus. Previous studies have shown that synaptic responses of these neurones are dominated by GABAergic inhibition. The present study describes intracellular recordings from 'fast-spiking' interneurones in layer II which may be the basis of the synaptic inhibition. Lucifer yellow fills of fast-spiking cells revealed neurones with a widespread axonal arborization forming basket-like complexes around unlabelled cells in layer II. Synaptic activation of the fast-spiking cells evoked long duration excitations which were mediated largely by NMDA receptors. A fast AMPA/kainate EPSP was also detectable. These neurones have morphological and physiological properties which make them well-suited to exert a widespread inhibitory control over the efferent output of layer II to the dentate gyrus.