Role of keratinocytes in healing of chronic wounds.
Role of keratinocytes in healing of chronic wounds.
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DOI：
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发表时间：
2008
影响因子：
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通讯作者：
I. Pastar;Olivera Stojadinović;M. Tomic-Canic
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作者：
I. Pastar;Olivera Stojadinović;M. Tomic-Canic
角质细胞是表皮的主要细胞成分，它们在伤口愈合过程中发挥着几种关键作用。它们参与伤口愈合的启动、维持和完成的复杂机制。角质形成细胞的性质根据其在慢性伤口内的位置和环境而变化。慢性伤口非愈合边缘的角质形成细胞不同于正常、健康的角质形成细胞。健康的角质形成细胞和参与伤口愈合的其他细胞类型之间的串扰对于成功的伤口闭合至关重要。这一发现为清创术提供了生物学基础：从静止的伤口边缘去除“坏”细胞，暴露或甚至用具有高再生潜力的“健康”细胞替换它们，可以增强上皮形成和慢性伤口的愈合。本文将综述角质形成细胞的生物学和病理学特性，因为它们与伤口愈合，以及它们可以为慢性伤口患者提供高效治疗的方式。
Keratinocytes are the major cellular component of epidermis, and they have several critical roles in the wound healing process. They are involved in the intricate mechanisms of initiation, maintenance, and completion of wound healing. The properties of keratinocytes vary depending upon their location and circumstances within chronic wounds. Keratinocytes at the non-healing edges of chronic wounds differ from normal, healthy keratinocytes. The cross-talk between healthy keratinocytes and other cell types participating in wound healing is critical for successful wound closure. This discovery provides the biological foundation for debridement: Removing "bad" cells from a quiescent wound edge and exposing or even replacing them with "healthy" cells with a high regenerative potential can enhance epithelialization and healing of chronic wounds. This paper will review the biological and pathological properties of keratinocytes as they relate to wound healing, and the ways in which they may provide highly efficacious therapy for patients with chronic wounds.