Friedel-Crafts Reaction of Indoles with Isatin-Derived beta,gamma-Unsaturated alpha-Keto Esters Using a BINOL-Derived Bisoxazoline (BOX)/Copper(II) Complex as Catalyst
Friedel-Crafts Reaction of Indoles with Isatin-Derived beta,gamma-Unsaturated alpha-Keto Esters Using a BINOL-Derived Bisoxazoline (BOX)/Copper(II) Complex as Catalyst
复制标题
使用联醇衍生的双恶唑啉 (BOX)/铜 (II) 络合物作为催化剂，吲哚与靛红衍生的 β,γ-不饱和 α-酮酯发生傅克反应
DOI：
10.1002/adsc.201600272
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发表时间：
2016
影响因子：
5.4
通讯作者：
Wang Xing-Wang
中科院分区：
文献类型：
--
作者：
Li Nai-Kai;Kong Ling-Pei;Qi Zhcng-Hang;Yin Shao-Jie;Zhang Jun-Qi;Wu Bing;Wang Xing-Wang
Several chiral BINOL-derived bisoxazoline (BOX)/copper(II) complexes were synthesizedand evaluated as catalysts for the Friedel–Crafts reaction of indoles with isatin-derived b,g-unsaturated a-keto esters. Theresulting bis-indole productsbearing aquaternary stereocenter were obtained in excellent yields and enantioselectivities.Additionally,the desired productsw erep ractically transformed to aamino esters, a-hydroxyesters and a-keto amides.I t.is noteworthy that this catalytic procedure was conducted with acatalyst loadingof0 .5 mol% without any discernible decrease in the reactivity or enantioselectivity..
