Xenobiotic exposure and autoimmune hepatitis.
Xenobiotic exposure and autoimmune hepatitis.
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DOI：
10.1155/2010/248157
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Gilbert KM
中科院分区：
文献类型：
--
作者：
Gilbert KM
尽管遗传学有助于自身免疫性疾病的发展，但显然也需要“环境”因素。这些因素被认为包括接触某些药物和环境污染物。本文研究了通常维持肝脏免疫无反应的机制，并讨论了接触某些异生物质（例如三氯乙烯）如何可能破坏这些机制并促进自身免疫性肝炎。
Although genetics contributes to the development of autoimmune diseases, it is clear that “environmental” factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis.