Transfer of glyburide and glipizide into breast milk
Transfer of glyburide and glipizide into breast milk
复制标题
DOI：
10.2337/diacare.28.8.1851
复制
发表时间：
2005-08-01
期刊：
影响因子：
16.2
通讯作者：
Koren, G
中科院分区：
文献类型：
--
作者：
Feig, DS;Briggs, GG;Koren, G
目的-为了确定是否格列本脲和格列吡嗪被排泄到母乳中，如果母乳喂养的妇女服用这些药物会导致婴儿低血糖症。研究设计和方法-我们研究了8名妇女谁收到了一个单一的口服剂量的5或10毫克格列本脲。给药后8 h测量母体血液和乳汁中的药物浓度。在另一项研究中，5名妇女从产后第一天开始每天服用格列本脲或格列吡嗪（5 mg/天）。产妇血液和牛奶中的药物浓度和婴儿血糖测定5-16天后deliver.Results -在单剂量格列本脲的研究中，平均最大理论婴儿剂量（MTID）作为体重调整的母亲剂量（WAMD）的百分比分别为< 1.5和< 0.7%的5-和10-mg剂量，分别。对于每日服用剂量的5名女性，格列本脲的平均MTID占WAMD的百分比< 28%，格列吡嗪< 27%。高估计值是由于测定的不敏感性。无论是格列本脲，也没有格列吡嗪在母乳中检测到的研究和血糖是正常的三个格列吡嗪谁是完全母乳喂养时，药物浓度处于稳态。结论-既没有格列本脲，也没有格列吡嗪在母乳中检测到，低血糖没有观察到在三个哺乳婴儿。两种药剂在测试剂量下似乎与母乳喂养相容。
OBJECTIVE - To determine if glyburide and glipizide are excreted into breast milk and if breast-feeding from women taking these drugs causes infant hypoglycemia.RESEARCH DESIGN AND METHODS - We studied eight women who had received a single oral dose of 5 or 10 mg glyburide. Drug concentrations were measured in maternal blood and milk for 8 h after the dose. In a separate study, five women were given a daily dosage (5 mg/day) of glyburide or glipizide, starting on the first postpartum day. Maternal blood and milk drug concentrations and infant blood glucose were measured 5-16 days after delivery.RESULTS - in the single-dose glyburide study, the mean maximum theoretical infant dose (MTID) as a percent of the weight-adjusted maternal dose (WAMD) was < 1.5 and < 0.7% for the 5- and 10-mg doses, respectively. For the five women taking daily dosages, the mean MTID as a percent of the WAMD was < 28% for glyburide and < 27% for glipizide. The high estimates were due to the insensitivity of the assay. Neither glyburide nor glipizide were detected in breast milk in either study and blood glucose was normal in the three in glipizide who were wholly breast-fed when the drug concentrations were at steady state.CONCLUSIONS - Neither glyburide nor glipizide were detected in breast milk, and hypoglycemia was not observed in the three nursing infants. Both agents, at the doses tested, appear to be compatible with breast-feeding.