Mechanoresponsive Properties of the Periodontal Ligament
Mechanoresponsive Properties of the Periodontal Ligament
复制标题
牙周膜的机械反应特性
DOI：
10.1177/0022034515626102
复制
发表时间：
2016-04-01
影响因子：
7.6
通讯作者：
Helms, J. A.
中科院分区：
文献类型：
--
作者：
Huang, L.;Liu, B.;Helms, J. A.
牙周膜（PDL）作为附着点发挥作用，是一种结缔组织附着物，可以消除机械负荷产生的应变。附着点是机械响应结构，能够快速适应其机械载荷的变化;在这里，我们询问PDL的哪些特征对这种体内载荷敏感。我们评估了PDL在4个生理相关的机械环境中，重点是有丝分裂活性，细胞密度，胶原蛋白含量，成骨蛋白表达和组织的组织。除了检查在咀嚼负荷和萌出力下支持牙齿的PDL外，还创建并分析了2个额外的机械条件：低负荷和实验性牙齿移动。总的来说，这些数据表明，成人牙周膜是一个显着的静止组织，只有当它受到增加的负荷，如与咀嚼，萌出，正畸牙齿移动的组织增加其细胞增殖率和胶原蛋白的生产。这些数据在临床场景中具有相关性，其中PDL适应可以用于优化牙齿移动。
The periodontal ligament (PDL) functions as an enthesis, a connective tissue attachment that dissipates strains created by mechanical loading. Entheses are mechanoresponsive structures that rapidly adapt to changes in their mechanical loading; here we asked which features of the PDL are sensitive to such in vivo loading. We evaluated the PDL in 4 physiologically relevant mechanical environments, focusing on mitotic activity, cell density, collagen content, osteogenic protein expression, and organization of the tissue. In addition to examining PDLs that supported teeth under masticatory loading and eruptive forces, 2 additional mechanical conditions were created and analyzed: hypoloading and experimental tooth movement. Collectively, these data revealed that the adult PDL is a remarkably quiescent tissue and that only when it is subjected to increased loads—such as those associated with mastication, eruption, and orthodontic tooth movement—does the tissue increase its rate of cell proliferation and collagen production. These data have relevance in clinical scenarios where PDL acclimatization can be exploited to optimize tooth movement.