Asymmetric 1,4‐Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2‐Aryltetralones
Asymmetric 1,4‐Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2‐Aryltetralones
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DOI：
10.1002/adsc.200600632
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发表时间：
2007-03
影响因子：
5.4
通讯作者：
N. Tokunaga;Tamio Hayashi
中科院分区：
文献类型：
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作者：
N. Tokunaga;Tamio Hayashi
以（R，R）-Ph-bod* 为配体的铑配合物为催化剂，通过芳基硼酸与萘醌单缩酮的不对称1，4-加成反应，合成了高ee值的2-芳基四氢萘酮。不对称加成反应产率高，对映选择性好。
A novel synthetic approach to 2-aryltetralones with high ee has been developed through asymmetric 1,4-addition of arylboronic acids to naphthoquinone monoketals catalyzed by a rhodium complex with the (R,R)-Ph-bod* ligand. The asymmetric addition proceeded in high yields with excellent enantioselectivity.