Myelin proteolipid protein - the first 50 years
Myelin proteolipid protein - the first 50 years
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DOI：
10.1016/s1357-2725(01)00136-4
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发表时间：
2002-03-01
影响因子：
4
通讯作者：
Lees, MB
中科院分区：
文献类型：
--
作者：
Greer, JM;Lees, MB
髓鞘蛋白脂质蛋白（PLP）是中枢神经系统髓鞘中含量最丰富的蛋白质，是一种疏水性的膜蛋白。由于其物理性质，使其难以工作，确定髓鞘PLP的确切功能和疾病相关性的进展缓慢。然而，最近的分子生物学进展为PLP的研究提供了新的生命，并表明它在髓鞘内具有多种功能，在几种神经系统疾病中具有重要意义。(C)2002爱思唯尔科技有限公司版权所有。
Myelin proteolipid protein (PLP), the most abundant protein of central nervous system (CNS) myelin, is a hydrophobic integral membrane protein. Because of its physical properties, which make it difficult to work with, progress towards determining the exact function(s) and disease associations of myelin PLP has been slow. However, recent molecular biology advances have given new life to investigations of PLP, and suggest that it has multiple functions within myelin and is of importance in several neurological disorders. (C) 2002 Elsevier Science Ltd. All rights reserved.