Benzodiazepine-induced amnesia in rats: reinstatement of conditioned performance by noxious stimulation on test.
Benzodiazepine-induced amnesia in rats: reinstatement of conditioned performance by noxious stimulation on test.
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苯二氮卓诱导的大鼠遗忘症：通过测试中的有害刺激恢复条件性能。
DOI：
10.1037//0735-7044.112.1.183
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发表时间：
1998
影响因子：
1.9
通讯作者：
R. F. Westbrook
中科院分区：
文献类型：
--
作者：
Justin A. Harris;R. F. Westbrook
苯二氮卓类药物（咪达唑仑），全身或直接注射到基底外侧杏仁核（BLA），差异影响收购的恐惧反应，以震惊的情况下：管理前的药物条件损害随后冻结的情况下，但幸免于镇痛反应在那里测试大鼠对福尔马林疼痛的敏感性。此外，疼痛试验不仅揭示了镇痛反应的证据，而且还恢复了条件冻结，否则在咪达唑仑条件下的大鼠中不存在。这些结果被解释为表明，测试中伤害性刺激的存在可以（a）帮助检索其存储已被咪达唑仑在BLA中的作用所改变的背景-休克关联，或者（B）使其情感特性已被咪达唑仑在BLA中的作用所阻断的背景-休克关联能够执行。
A benzodiazepine (midazolam), injected either systemically or directly into the basolateral amygdala (BLA), differentially affected the acquisition of fear responses to a shocked context: Administration of the drug before conditioning impaired subsequent freezing to the context but spared analgesic responses in rats tested there for sensitivity to formalin pain. Moreover, the pain test not only revealed evidence for analgesic responses but also served to reinstate conditioned freezing that was otherwise absent in rats conditioned under midazolam. The results were interpreted as showing that the presence of noxious stimulation on test serves either (a) to assist in retrieval of the context-shock association whose storage had been modified by midazolam's action in the BLA, or (b) to enable performance of the context-shock association whose affective properties had been blocked by midazolam's action in the BLA.