Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats
Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats
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DOI：
10.1016/s0304-3940(02)01391-5
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发表时间：
2003-02-27
影响因子：
2.5
通讯作者：
Rattray, M
中科院分区：
文献类型：
--
作者：
File, SE;Hartley, DE;Rattray, M
成年雄性兜帽李斯特大鼠喂食含有150 μ g/g大豆植物雌激素的饮食或不含大豆的饮食18天。这种植物雌激素的浓度应该足以占据雌激素-β，但不是雌激素-α，受体。使用原位杂交，显着减少脑源性神经营养因子（BDNF）的mRNA表达在CA 3和CA 4区的海马和大脑皮质中的大鼠喂养的饮食含有植物雌激素，与那些对大豆自由饮食。谷氨酸脱羧酶-67和胶质细胞酸性蛋白mRNA的表达没有变化，提示雌激素β受体在调节BDNF mRNA表达中起作用。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Adult male hooded Lister rats were either fed a diet containing 150 mug/g soya phytoestrogens or a soya-free diet for 18 days. This concentration of phytoestrogens should have been sufficient to occupy the oestrogen-beta, but not the oestrogen-alpha, receptors. Using in situ hybridisation, significant reductions were found in brain-derived neurotrophic factor (BDNF) mRNA expression in the CA3 and CA4 region of the hippocampus and in the cerebral cortex in the rats fed the diet containing phytoestrogens, compared with those on the soya-free diet. No changes in glutamic acid decarboxylase-67 or glial fibrillary acidic protein mRNA were found. This suggests a role for oestrogen-beta receptors in regulating BDNF mRNA expression. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.