Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats.
Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats.
复制标题
在戊四唑诱导大鼠癫痫发作期间用三极同心环电极记录高频振荡的可行性。
DOI：
10.1109/embc.2012.6346991
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Besio,WalterG
中科院分区：
文献类型：
--
作者：
Makeyev,Oleksandr;Liu,Xiang;Wang,Liling;Zhu,Zhenghan;Taveras,Aristides;Troiano,Derek;Medvedev,AndreiV;Besio,WalterG
由于癫痫在大约30%的复杂部分性癫痫患者中仍然是一种难治性疾病，脑电刺激最近显示出附加癫痫控制治疗的潜力。在此之前，我们通过新型三极同心圆电极（TCREs）在大鼠用戊四唑（PTZ）诱导癫痫发作后的头皮上应用无创经颅局灶刺激。我们开发了一个闭环系统来检测癫痫发作并自动触发刺激，并评估其对大鼠TCREs记录的电图活动的影响。在我们之前的工作中，癫痫发作的检测器是基于癫痫引起的频率范围高达100 Hz的信号功率变化，而在这项初步研究中，我们评估了在ptz引起的癫痫发作期间使用头皮TCREs无创记录高达300 Hz范围内高频振荡（HFOs）的可行性。采用大平均功率谱密度估计和广义似然比检验比较各组大鼠癫痫发作不同阶段的电活动功率（n= 8）。结果表明，TCREs有能力记录头皮上的hfo，并且头皮上记录的hfo可能被用作癫痫发作检测的特征。
As epilepsy remains a refractory condition in about 30% of patients with complex partial seizures, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. Previously, we applied noninvasive transcranial focal stimulation via novel tripolar concentric ring electrodes (TCREs) on the scalp of rats after inducing seizures with pentylenetetrazole (PTZ). We developed a close-loop system to detect seizures and automatically trigger the stimulation and evaluated its effect on the electrographic activity recorded by TCREs in rats. In our previous work the detectors of seizure onset were based on seizure-induced changes in signal power in the frequency range up to 100 Hz, while in this preliminary study we assess the feasibility of recording high frequency oscillations (HFOs) in the range up to 300 Hz noninvasively with scalp TCREs during PTZ-induced seizures. Grand average power spectral density estimate and generalized likelihood ratio tests were used to compare power of electrographic activity at different stages of seizure development in a group of rats (n= 8). The results suggest that TCREs have the ability to record HFOs from the scalp as well as that scalp-recorded HFOs can potentially be used as features for seizure onset detection.