Adults with attention-deficit/hyperactivity disorder - A diffusion-tensor imaging study of the corpus callosum
Adults with attention-deficit/hyperactivity disorder - A diffusion-tensor imaging study of the corpus callosum
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DOI：
10.1016/j.pscychresns.2011.08.005
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发表时间：
2012-02-28
影响因子：
2.3
通讯作者：
Plessen, Kerstin J.
中科院分区：
文献类型：
--
作者：
Dramsdahl, Margaretha;Westerhausen, Rene;Plessen, Kerstin J.
本研究的目的是通过磁共振成像（MRI）研究注意缺陷多动障碍（ADHD）成人胼胝体（CC）的微观结构和宏观结构。来自挪威卑尔根ADHD项目的29名ADHD参与者和37名对照者。我们测量的分数各向异性（FA）值，以及不同的细分的CC的大小，使用扩散张量成像（DTI）和解剖MRI。与对照组相比，ADHD组CC的峡部/压部部分显示FA值降低，而CC的大小在各组之间没有差异。因此，我们的研究结果表明，ADHD成人CC的微观结构和宏观结构的措施之间的分歧。这与儿童胼胝体微观结构和宏观结构异常的结果形成对比。我们的研究结果可能表明，成人多动症的一部分已经成功地通过了早期的发展延迟的CC，导致正常化的胼胝体宏观结构进入成年期。然而，成年人的微结构差异仍然存在，这可能表明ADHD成年人的异常偏侧化，或者可能是持续性损伤的迹象。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
The objective of the present study was to investigate the microstructure and the macrostructure of the corpus callosum (CC) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) by means of magnetic resonance imaging (MRI). Twenty-nine participants with ADHD and 37 controls were included from the Norwegian ADHD project in Bergen. We measured the fractional anisotropy (FA) values, as well as the size of different subdivisions of the CC, using diffusion tensor imaging (DTI) and anatomical MRI. The isthmus/splenium part of the CC in the ADHD group showed reduced FA values compared to the control group, whereas the size of the CC did not differ across groups. Our findings thus demonstrate a divergence between microstructural and macrostructural measures in the CC of adults with ADHD. This contrasts with findings in children demonstrating callosal abnormalities in both microstructure and macrostructure. Our results may indicate that adults with ADHD in part have succeeded in passing by an earlier developmental delay of the CC, resulting in a normalization of callosal macrostructure into adulthood. However, microstructural differences are still present in adults, which may point to an abnormal lateralization in adults with ADHD, or could be a sign of a persisting impairment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.