Pure total flavonoids from citrus improve nonalcoholic steatohepatitis liver inflammatory responses by regulating the CCL2/CCR2‐PI3K‐Akt signal transduction pathway
Pure total flavonoids from citrus improve nonalcoholic steatohepatitis liver inflammatory responses by regulating the CCL2/CCR2‐PI3K‐Akt signal transduction pathway
复制标题
DOI：
10.1002/ar.25117
复制
发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Liyan Wu;Zengsheng Lu;Beihui He;Jianshun Yu;Maoxiang Yan;Jianping Jiang;Zhiyun Chen
中科院分区：
文献类型：
--
作者：
Liyan Wu;Zengsheng Lu;Beihui He;Jianshun Yu;Maoxiang Yan;Jianping Jiang;Zhiyun Chen
非酒精性脂肪性肝炎(NASH)是非酒精性脂肪性肝病(NAFLD)预后的关键阶段。马戏团纯总黄酮类化合物(PTFC)在改善NASH症状方面发挥了重要作用，但其潜在的调节机制仍不清楚。我们先前的高通量组学筛选结果表明，CCL2/CCR2-PI3K-Akt信号通路是调节肝脏炎症反应的关键途径。PTFC可能通过调节CCL2/CCR2-PI3K-Akt信号通路，改善肝脏炎症反应。
Nonalcoholic steatohepatitis (NASH) is a critical stage in the prognosis of nonalcoholic fatty liver disease (NAFLD). Pure total flavonoids from circus (PTFC) play essential roles in the improvement of NASH symptoms, but the underlying regulatory mechanism remains elusive. Our previous high‐throughput omics screening results indicate that the CCL2/CCR2‐PI3K‐Akt signaling pathway is a key pathway that regulates the liver inflammatory response. PTFC may regulate the CCL2/CCR2‐PI3K‐Akt signaling pathway to improve the liver inflammatory response.