Connections between the nucleus isthmi and the tectum in larval and post-metamorphic axolotls.

Connections between the nucleus isthmi and the tectum in larval and post-metamorphic axolotls.
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幼虫和变态后蝾螈的峡核和顶盖之间的连接。

DOI:
10.1002/neu.480190202
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发表时间:
1988
期刊:
Journal of neurobiology
影响因子:
--
通讯作者:
Udin,SB
Udin,SB
中科院分区:
--
文献类型:
--
作者:
Fisher,MD;Udin,SB

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峡核是蛙同侧视顶盖投射的主要中继。使用电生理学方法,同侧视顶盖活动已被记录在甲状腺素治疗,postmetamorphic蝾螈,但没有在幼虫蝾螈。为了确定是否峡顶盖预测的变化是负责这种变化的电生理反应,我们已经调查了顶盖和NI之间的连接,使用辣根过氧化物酶。我们的研究结果表明,蝾螈的峡顶盖途径是惊人的相似,青蛙NI,NI发送双边的预测,在幼虫和甲状腺素治疗,postmetamorphic蝾螈顶盖。因此,解剖学连接的基础上的同侧visuotectal投影是存在于幼虫阶段,尽管缺乏电生理证据的幼虫同侧visuotectal投影。我们假设甲状腺素诱导的变态在交叉峡顶盖投射的终末分支中产生变化,这使得它们可以通过突触前电生理技术检测到。
The nucleus isthmi (NI) is the primary relay for the frog's ipsilateral visuotectal projection. Using electrophysiological methods, ipsilateral visuotectal activity has been recorded in thyroxine‐treated, postmetamorphic axolotls but not in larval axolotls. In order to determine whether changes in isthmotectal projections are responsible for this change in electrophysiological responsiveness, we have investigated the connections between the tectum and the NI using horseradish peroxidase. Our results indicate that the axolotl's isthmotectal pathways are strikingly similar to those of the frog NI, and that the NI sends bilateral projections to the tecta in both larval and thyroxine‐treated, postmetamorphic axolotls. Thus, the anatomical connections underlying the ipsilateral visuotectal projection are present during larval stages, despite the lack of electrophysiological evidence for the larval ipsilateral visuotectal projection. We hypothesize that thyroxine‐induced metamorphosis produces changes in the terminal arborizations of the crossed isthmotectal projection which allow them to be detected by presynaptic electrophysiological techniques.
DOI: 10.1002/cne.901650303
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