IDENTIFICATION OF A DROSOPHILA MUSCLE DEVELOPMENT GENE WITH STRUCTURAL HOMOLOGY TO MAMMALIAN EARLY GROWTH-RESPONSE TRANSCRIPTION FACTORS
IDENTIFICATION OF A DROSOPHILA MUSCLE DEVELOPMENT GENE WITH STRUCTURAL HOMOLOGY TO MAMMALIAN EARLY GROWTH-RESPONSE TRANSCRIPTION FACTORS
复制标题
DOI：
10.1073/pnas.92.22.10344
复制
发表时间：
1995-10-24
影响因子：
11.1
通讯作者：
TANOUYE, MA
中科院分区：
文献类型：
--
作者：
LEE, JC;VIJAYRAGHAVAN, K;TANOUYE, MA
在果蝇中，条纹 (sr) 基因功能是正常肌肉发育所必需的。有些突变会破坏胚胎肌肉的发育并且是致命的。其他突变导致成人仅完全丧失一块肌肉。分子分析表明 sr 编码含有锌指基序的预测蛋白质。该基序与早期生长反应 (egr) 基因家族成员编码的 DNA 结合域同源。在哺乳动物中，egr 基因的表达是由细胞间信号诱导的，并且有证据表明它们在许多发育事件中发挥作用。 sr 作为 egr 基因的鉴定及其表达模式表明它通过细胞间通讯在肌肉发育中发挥作用。
In Drosophila, stripe (sr) gene function is required for normal muscle development. Some mutations disrupt embryonic muscle development and are lethal. Other mutations cause total loss of only a single muscle in the adult. Molecular analysis shows that sr encodes a predicted protein containing a zinc finger motif. This motif is homologous to the DNA binding domains encoded by members of the early growth response (egr) gene family. In mammals, expression of egr genes is induced by intercellular signals, and there is evidence for their role in many developmental events. The identification of sr as an egr gene and its pattern of expression suggest that it functions in muscle development via intercellular communication.