A developmentally regulated membrane protein gene in Dictyostelium discoideum is also induced by heat shock and cold shock
A developmentally regulated membrane protein gene in Dictyostelium discoideum is also induced by heat shock and cold shock
复制标题
盘基网柄菌中发育调节的膜蛋白基因也受到热休克和冷休克的诱导
DOI：
--
复制
发表时间：
1988
影响因子：
5.3
通讯作者：
W. Nellen
中科院分区：
文献类型：
--
作者：
M. Maniak;W. Nellen
我们分析了从一个早期发育调控基因中分离到的网柄菌基因P8A7的表达情况。单个基因组拷贝产生了两个受不同调控机制控制的mRNAs：一个mRNA(P8A7S)像细胞类型非特异性晚期基因一样受到调控，另一个(P8A7L)在发育过程中、细胞被允许附着在底物上时以及当细胞受到压力(如热休克和镉)时被诱导。有趣的是，在冷休克中也观察到了同样的诱导。RNA的加工受到热和冷冲击的抑制，导致前体的核积累。该基因的翻译区是两个mRNAs共有的，编码一种具有膜蛋白特征的异常疏水的多肽。
We have analyzed the expression of the Dictyostelium gene P8A7 which had been isolated as a cDNA clone from an early developmentally regulated gene. The single genomic copy generated two mRNAs which were subject to different control mechanisms: while one mRNA (P8A7S) was regulated like the cell-type-nonspecific late genes, the other one (P8A7L) was induced during development, when cells were allowed to attach to a substrate, and when cells were subjected to stress, such as heat shock and cadmium. Interestingly the same induction was also observed with cold shock. RNA processing was inhibited by heat and cold shock, leading to nuclear accumulation of a precursor. The translated region of the cDNA was common to both mRNAs and encoded an unusually hydrophobic peptide with the characteristics of a membrane protein.
盘基网柄菌中控制环 AMP 调节和细胞类型特异性表达的前柄特异性基因的序列的鉴定。
影响因子：
5.3
作者：
Datta,S;Firtel,RA
通讯作者：
Firtel,RA