Developmental changes of prefrontal activation in humans: a near-infrared spectroscopy study of preschool children and adults.
Developmental changes of prefrontal activation in humans: a near-infrared spectroscopy study of preschool children and adults.
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DOI：
10.1371/journal.pone.0025944
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Kasai K
中科院分区：
文献类型：
--
作者：
Kawakubo Y;Kono T;Takizawa R;Kuwabara H;Ishii-Takahashi A;Kasai K
以往的形态学研究表明，人类前额叶皮质(PFC)的发育似乎一直持续到青春期晚期。尽管功能脑成像研究试图确定PFC功能发育的时间进程，但由于参与者的年龄范围狭窄或不连续，目前尚不清楚这种发育变化是否发生在青春期到成年期之后，以及何时达到顶峰。此外，以往的功能研究还没有集中在前额叶区域，即额叶极区(BA9/10)。因此，本研究采用近红外光谱(NIRS)技术，从学龄前儿童到成人，研究了与字母流利性任务相关的额叶PFC激活的发育变化。我们分析了48名典型发育的儿童和青少年和22名健康成人在激活任务中测量的前额叶皮质中血红蛋白(ΔHb)的相对浓度。与以往的形态学研究一致，我们发现儿童/青少年的发育随年龄而变化。此外，成年男性的平均Δ-OXY-Hb显著大于儿童/青少年男性，而女性则不是这样。这些数据表明，PFC的功能发育一直持续到青春期后期。尽管从儿童期到青春期，额叶PFC的发育变化不受性别的影响，但成年后表现出性别差异。
Previous morphological studies indicated that development of the human prefrontal cortex (PFC) appears to continue into late adolescence. Although functional brain imaging studies have sought to determine the time course of functional development of the PFC, it is unclear whether the developmental change occurs after adolescence to adulthood and when it achieves a peak because of the narrow or discontinuous range in the participant's age. Moreover, previous functional studies have not focused on the anterior frontal region, that is, the frontopolar regions (BA9/10). Thus, the present study investigated the developmental change in frontopolar PFC activation associated with letter fluency task by using near-infrared spectroscopy (NIRS), in subjects from preschool children to adults. We analyzed the relative concentration of hemoglobin (ΔHb) in the prefrontal cortex measured during the activation task in 48 typically-developing children and adolescents and 22 healthy adults. Consistent with prior morphological studies, we found developmental change with age in the children/adolescents. Moreover, the average Δoxy-Hb in adult males was significantly larger than that in child/adolescent males, but was not true for females. These data suggested that functional development of the PFC continues into late adolescence. Although the developmental change of the frontopolar PFC was independent of gender from childhood to adolescence, in adulthood a gender difference was shown.