Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum: A Study Using a High-Resolution Semiconductor PET System
Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum: A Study Using a High-Resolution Semiconductor PET System
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DOI：
10.2967/jnumed.114.152504
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发表时间：
2015-08-01
影响因子：
9.3
通讯作者：
Tamaki, Nagara
中科院分区：
文献类型：
--
作者：
Hirata, Kenji;Hattori, Naoya;Tamaki, Nagara
红核（RN）是位于中脑的一对小的灰质结构，参与肌肉运动和认知功能。这项回顾性研究旨在研究人类RN的代谢及其与其他脑区的相关性。方法：我们开发了一个高分辨率的半导体PET系统，以成像小的大脑结构。20例无神经系统疾病的患者在注射400 MBq F-18-FDG后进行全脑扫描。使用三维立体定向表面投影技术，对单个脑F-18-FDG PET图像进行空间归一化以生成表面投影图。RN和大脑和小脑皮质上的每个体素之间的相关性用Pearson积矩相关分析进行估计。结果：右、左视神经核的摄取均高于背景中脑。RN的最大标准化摄取值为7.64 +/- 1.92;高于齿状核的值，但低于尾状核、壳核和丘脑的值。逐体素分析表明，右RN与同侧联合皮层的相关性高于对侧皮层，而左RN与同侧和对侧皮层的相关性相同。左侧RN与运动皮质和小脑的相关性强于右侧RN。结论：虽然RN周围的非特异性背景活动可能会影响相关模式，这些代谢关系表明，RN与联合皮层和边缘区进行更高的大脑功能。
The red nucleus (RN) is a pair of small gray matter structures located in the midbrain and involved in muscle movement and cognitive functions. This retrospective study aimed to investigate the metabolism of human RN and its correlation to other brain regions. Methods: We developed a high-resolution semiconductor PET system to image small brain structures. Twenty patients without neurologic disorders underwent whole-brain scanning after injection of 400 MBq of F-18-FDG. The individual brain F-18-FDG PET images were spatially normalized to generate a surface projection map using a 3-dimensional stereotactic surface projection technique. The correlation between the RN and each voxel on the cerebral and cerebellar cortices was estimated with Pearson product-moment correlation analysis. Results: Both right and left RNs were visualized with higher uptake than that in the background midbrain. The maximum standardized uptake values of RN were 7.64 +/- 1.92; these were higher than the values for the dentate nucleus but lower than those for the caudate nucleus, putamen, and thalamus. The voxel-by-voxel analysis demonstrated that the right RN was correlated more with ipsilateral association cortices than contralateral cortices, whereas the left RN was equally correlated with ipsilateral and contralateral cortices. The left RN showed a stronger correlation with the motor cortices and cerebellum than the right RN did. Conclusion: Although nonspecific background activity around RNs might have influenced the correlation patterns, these metabolic relationships suggested that RN cooperates with association cortices and limbic areas to conduct higher brain functions.