Effect of the absorption enhancer saponin on the intrarenal distribution of 5-fluorouracil following its kidney surface application in rats.
Effect of the absorption enhancer saponin on the intrarenal distribution of 5-fluorouracil following its kidney surface application in rats.
复制标题
吸收促进剂皂苷对大鼠肾脏表面应用后5-氟尿嘧啶肾内分布的影响。
DOI：
10.1248/bpb.26.1049
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发表时间：
2003
影响因子：
2
通讯作者：
K. Nishida
中科院分区：
文献类型：
--
作者：
J. Nakamura;Tomomi Horimoto;R. Hirayama;T. Mukai;M. Nakashima;H. Sasaki;K. Nishida
本文研究了吸收促进剂皂苷对大鼠肾表面应用5-氟尿嘧啶(5-FU)后肾内分布的影响。我们选择了一种实验系统，利用附着在肾脏表面的圆柱形扩散池。右肾表面应用0.25和1 mg/ml5-FU加皂苷后120分钟肾内5-FU浓度改变。在右肾四个部位，皂苷可选择性升高弥散细胞下的5-FU浓度。这些结果表明，在肾脏表面使用吸收促进剂后，控制药物在肾内的分布是可能的。
The present study was undertaken to examine the effects of the absorption enhancer saponin on the intrarenal distribution of 5-fluorouracil (5-FU) following the kidney surface application of 5-FU in rats. We selected an experimental system utilizing a cylindrical diffusion cell attached to the kidney surface. The intrarenal concentration of 5-FU 120 min after right kidney surface application of 5-FU with saponin at concentrations of 0.25 and 1 mg/ml was modified. Among four sites in the right kidney, the concentration of 5-FU under the diffusion cell was selectively increased by saponin. These results suggest it may be possible to control the intrarenal distribution of the drug following its application with an absorption enhancer on the kidney surface.