Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults.
Elevated serum IL-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults.
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DOI：
10.2147/cia.s180934
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发表时间：
2018
影响因子：
3.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Ma L;Sha G;Zhang Y;Li Y
虚弱与不利的健康后果有关。它的生物标志物对于提高诊断的简便性至关重要，并将有助于对这种情况的监测。考虑到促炎状态和营养状态与虚弱的关系，我们的目的是调查炎症介质和脂肪因子是否与虚弱有关，以及它们与身体功能的关系。我们招募了130名老年人(90名非虚弱参与者和40名虚弱参与者，平均年龄：72.80±8.61岁)，他们接受了全面的病史和虚弱评估。比较两组的生化指标(如血尿素氮、高密度脂蛋白、血红蛋白)、胰岛素途径(葡萄糖、胰岛素、胰岛素样生长因子1)、循环炎症标志物(IL-6、肿瘤坏死因子受体1、C反应蛋白)和脂肪因子(脂联素、血管紧张素、瘦素)。我们进一步分析了它们与身体机能的相关性。与非虚弱的参与者相比，虚弱的老年人表现出更高的BUN、IL-6、脂联素、vaspin和血糖水平，而更低的IGF-1、高密度脂蛋白和HGB水平。血清IL-6水平与握力(P=0.03)和步速(P=0.04)呈负相关。循环脂联素和瘦素水平分别与握力(P=0.01)和步速(P=0.03)呈负相关。在调整年龄和性别后，与身体功能相关的指标只有IL-6(r=−0.180，P=0.044)和脂联素(r=−0.195，P=0.029)。在虚弱的老年人中发现了高水平的IL-6、脂联素、vaspin和葡萄糖以及低水平的IGF-1。此外，IL-6、脂联素和瘦素水平与身体功能呈负相关，提示炎症介质和脂肪因子是老年人虚弱和功能下降的生物标志物。
Frailty is associated with adverse health outcomes. Its biological markers are essential to enhance diagnostic ease and would contribute to surveillance of the condition. Considering the involvement of pro-inflammatory and nutritional states in frailty, we aimed to investigate whether inflammatory mediators and adipokines are associated with frailty and their relationship with physical function. We recruited 130 older adults (90 nonfrail participants and 40 frail participants, mean age: 72.80±8.61 years) who underwent a comprehensive medical history and frailty assessment. The biochemical indicators (eg, blood urea nitrogen [BUN], high-density lipoprotein [HDL], and hemoglobin [HGB]), insulin pathway (glucose, insulin, and insulin-like growth factor 1 [IGF-1]), circulating inflammatory biomarkers (IL-6, tumor necrosis factor receptor 1, and C-reactive protein), and adipokines (adiponectin, vaspin, and leptin) were compared between the two groups. We further analyzed their correlation with physical function. Frail older adults showed higher levels of BUN, IL-6, adiponectin, vaspin, and glucose and lower levels of IGF-1, HDL, and HGB compared with nonfrail participants. Serum IL-6 levels were negatively correlated with both grip strength (P=0.03) and gait speed (P=0.04). Levels of circulating adiponectin and leptin were adversely correlated with grip strength (P=0.01) and gait speed (P=0.03), respectively. After adjustment for age and sex, the only markers correlated with physical function were IL-6 (r=−0.180, P=0.044) and adiponectin (r=−0.195, P=0.029). High levels of IL-6, adiponectin, vaspin, and glucose as well as low levels of IGF-1 were found in frail older adults. Furthermore, IL-6, adiponectin, and leptin levels were negatively correlated with physical function, suggesting that inflammatory mediators and adipokines are biomarkers for frailty and decreased function in older adults.