THE ORIGIN OF THE GLOMERULAR ENDOTHELIUM
THE ORIGIN OF THE GLOMERULAR ENDOTHELIUM
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DOI：
10.1016/0045-6039(82)90014-8
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
SAXEN, L
中科院分区：
文献类型：
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作者：
EKBLOM, P;SARIOLA, H;SAXEN, L
肾小球内皮的起源尚未确定，它可能像肾单位的其他部分一样，来自后肾间充质。由于最近的观察结果不支持这一概念，使用小鼠/鹌鹑和鹌鹑/鸡种间移植物研究了肾脏和肾小球内皮血管系统的发育。将未分化的11天小鼠肾原基移植到鹌鹑绒毛尿囊膜上，并允许发育7-10天。经检查，移植物血管化良好，肾小球和血管内皮细胞均表达鹌鹑核标记物。在鹌鹑/鸡移植实验中获得了类似的结果。显然，肾小球的内皮细胞来源于外部血管系统，而不是由肾间质中的细胞转化而来。
The origin of the glomerular endothelium is unsettled; it may be derived from the metanephric mesenchyme, like the other parts of the nephron. Since recent observations did not support this concept, development of the vasculature of the kidney and of the glomerular endothelium was studied using both mouse/quail and quail/chick interspecies grafts. Undifferentiated 11-day mouse kidney anlagen were transplanted onto quail chorioallantoic membrane and allowed to develop for 7-10 days. Upon examination, grafts were well-vascularized, and both the glomerular and the vessel endothelium expressed the quail nuclear marker. Similar results were obtained in quail/chick transplantation experiments. Apparently the endothelium of the glomeruli is derived from outside vasculature rather than by conversion of cells in the nephrogenic mesenchyme.