Long-term recovery of irradiated prostate cancer increases cancer stem cells.
Long-term recovery of irradiated prostate cancer increases cancer stem cells.
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DOI：
10.1002/pros.22527
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发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Hurt EM
中科院分区：
文献类型：
--
作者：
Cho YM;Kim YS;Kang MJ;Farrar WL;Hurt EM
尽管治疗有所改善，前列腺癌（PC）仍然是男性癌症死亡的第二大原因。放疗是前列腺癌的一线治疗方法之一，但有相当多的患者复发。最近的证据支持这样一种观点，即PC是由一种称为癌症干细胞（CSCs）的细胞亚群发起的。CSCs也与各种恶性肿瘤的放射耐药有关，但它们在PC中的作用尚未被研究。我们比较了分离的CSCs与其相应细胞系的相对放射敏感性，并检测了长期恢复后辐照细胞系和复发的人类前列腺癌中CSCs的相对数量。在这里，我们表明，虽然照射不会立即增加CSC的存活，但照射的PC细胞系在长期恢复中显示出CSC特性的增加。这些数据表明，尽管CSCs最初受到辐射损伤，但它们具有更大的恢复和再生能力。放疗与csc靶向治疗策略的结合可以预防肿瘤复发。
Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for prostate cancer, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated. We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human prostate cancer. Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth. The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence.
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影响因子：
11.2
作者：
Vander Griend DJ;Karthaus WL;Dalrymple S;Meeker A;DeMarzo AM;Isaacs JT
通讯作者：
Isaacs JT
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影响因子：
8.8
作者：
Hurt, E. M.;Kawasaki, B. T.;Klarmann, G. J.;Thomas, S. B.;Farrar, W. L.
通讯作者：
Farrar, W. L.
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影响因子：
3.6
作者：
Hermann, Robert Michael;Wolff, Hendrik Andreas;Jarry, Hubertus;Thelen, Paul;Gruendker, Carsten;Rave-Fraenk, Margret;Schmidberger, Heinz;Christiansen, Hans
通讯作者：
Christiansen, Hans
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.
鉴定非典型畸胎组织/色肽肿瘤中CD133阳性辐射细胞。
影响因子：
3.7
作者：
Chiou, Shih-Hwa;Kao, Chung-Lan;Chen, Yi-Wei;Chien, Chien-Shu;Hung, Shih-Chieh;Lo, Jeng-Fan;Chen, Yann-Jang;Ku, Hung-Hai;Hsu, Ming-Ta;Wong, Tai-Tong
通讯作者：
Wong, Tai-Tong