GABAergic projection from the arcuate nucleus to the supraoptic nucleus in the rat
GABAergic projection from the arcuate nucleus to the supraoptic nucleus in the rat
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DOI：
10.1016/s0304-3940(00)00846-6
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发表时间：
2000-03-10
影响因子：
2.5
通讯作者：
Leng, G
中科院分区：
文献类型：
--
作者：
Ludwig, M;Leng, G
电刺激下丘脑弓状核神经元可引起视上核大细胞神经元的短暂抑制和明显的刺激后兴奋。将γ-氨基丁酸（GABA（A））激动剂蝇蕈醇直接微透析注入视上核，可抑制催产素和加压素神经元，并可被GABA（A）拮抗剂荷包牡丹碱完全逆转。此外，荷包牡丹碱可阻断弓状核刺激引起的抑制，但对刺激后兴奋无影响。因此，从弓状核发出或通过弓状核到视上核的抑制通路的一部分是由神经递质GABA介导的。然而，弓状核刺激引起的抑制后兴奋不是反弹反应，而是涉及一个独立的兴奋通路。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Electrical stimulation of the neurones in the hypothalamic arcuate nucleus results in a transient inhibition followed by a marked post-stimulus excitation of magnocellular neurones Of the supraoptic nucleus. Microdialysis administration of the gamma-aminobutyric acid agonist (GABA(A)), muscimol, directly into the supraoptic nucleus inhibited both oxytocin and vasopressin neurones and these actio ns were fully reversed by the GABA(A) antagonist bicuculline, In addition, bicuculline administration blocked the inhibition induced by arcuate stimulation, but had no effect on the post-stimulus excitation. Thus, part of the inhibitory pathway arising from or passing through the arcuate nucleus to the supraoptic nucleus is mediated by the neurotransmitter GABA, However, the post-inhibitory excitation induced by arcuate stimulation is not a rebound response, but appears to involve an independent excitatory pathway. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.