Network dynamics.
Network dynamics.
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DOI：
10.1007/978-1-59745-243-4_13
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Sauro, Herbert M
中科院分区：
文献类型：
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作者：
Sauro, Herbert M
也许一个生命系统最典型的特征之一就是它不断变化的倾向，因为它在生存的需求和复制的需要之间摇摆不定。在内部，这些变化表现为代谢物、蛋白质和基因活性的变化。随着高通量技术的出现，这些变化对实验者来说变得越来越明显。在这一章中，我们强调了一些用于合理化细胞动力学研究的定量方法。本章重点关注基于微分方程的定量模型的分析，使用生化控制理论。讨论了基本的途径基序，包括直链，支链和环状系统。此外，一些属性所赋予的积极和消极的反馈回路进行了讨论，特别是在有关的双稳态和振荡动力学。
Probably one of the most characteristic features of a living system is its continual propensity to change as it juggles the demands of survival with the need to replicate. Internally these changes are manifest as changes in metabolite, protein and gene activities. Such changes have become increasingly obvious to experimentalists with the advent of high-throughput technologies. In this chapter we highlight some of the quantitative approaches used to rationalize the study of cellular dynamics. The chapter focuses attention on the analysis of quantitative models based on differential equations using biochemical control theory. Basic pathway motifs are discussed, including straight chain, branched and cyclic systems. In addition, some of the properties conferred by positive and negative feedback loops are discussed particularly in relation to bistability and oscillatory dynamics.