Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles
Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles
复制标题
DOI：
10.1002/smll.201101980
复制
发表时间：
2012-03-12
期刊：
影响因子：
13.3
通讯作者：
Graham, Duncan
中科院分区：
文献类型：
--
作者：
Krpetic, Zeljka;Guerrini, Luca;Graham, Duncan
使用金纳米颗粒沿着与表面增强拉曼光谱（Sers）的分析物的比色检测是激烈的研究活动的领域，因为它们都提供非常低浓度的目标物质的感测。多模态检测促进了通过不同技术的组合对样品的同时检测;因此，在多模态纳米传感器的开发中的表面化学设计对于通过多种分析方法对分析物进行快速和灵敏的评估是重要的。在本文中，它表明，纳米粒子的大小起着重要的作用，在设计的功能性纳米粒子的比色和基于SERS的传感应用，允许控制纳米粒子组装和可调传感器响应。稳健的纳米粒子系统及其组装的设计和制备报告痕量检测Ni（II）离子作为模型系统在水溶液中。共价连接的次氮基三乙酸部分与纳米颗粒表面上的L-肌肽二肽沿着的组合代表了用于快速和选择性检测Ni（II）离子的高度灵敏的平台。这项系统的研究表明，显着降低检测限可以通过微调不同核心大小的金纳米粒子的组装实现。结果清楚地表明了多模式方法的可行性和实用性。
Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection promotes the simultaneous detection of a sample by a combination of different techniques; consequently, surface chemistry design in the development of multimodal nanosensors is important for rapid and sensitive evaluation of the analytes by diverse analytical methods. Herein it is shown that nanoparticle size plays an important role in the design of functional nanoparticles for colorimetric and SERS-based sensing applications, allowing controlled nanoparticle assembly and tunable sensor response. The design and preparation of robust nanoparticle systems and their assembly is reported for trace detection of Ni(II) ions as a model system in an aqueous solution. The combination of covalently attached nitrilotriacetic acid moieties along with the L-carnosine dipeptide on the nanoparticle surface represents a highly sensitive platform for rapid and selective detection of Ni(II) ions. This systematic study demonstrates that significantly lower detection limits can be achieved by finely tuning the assembly of gold nanoparticles of different core sizes. The results clearly demonstrate the feasibility and usefulness of a multimodal approach.