Vascular Health and Risk Management Dovepress Effect of Melatonin on Nocturnal Blood Pressure: Meta-analysis of Randomized Controlled Trials
Vascular Health and Risk Management Dovepress Effect of Melatonin on Nocturnal Blood Pressure: Meta-analysis of Randomized Controlled Trials
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通讯作者：
E. Grossman;M. Laudon;N. Zisapel
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作者：
E. Grossman;M. Laudon;N. Zisapel
背景资料：夜间高血压患者发生心血管并发症的风险较高，如心肌梗死和脑血管损伤。已发表的研究不一致地报告了褪黑激素降低夜间血压的作用。研究方法：采用符合纳入标准的所有研究的随机效应模型，对外源性褪黑素改善夜间血压的有效性和安全性进行荟萃分析，并对速释制剂与控释制剂进行亚组分析。结果：纳入了7项试验（3项控释褪黑激素和4项快速释放褪黑激素），共有221名参与者。所有7项研究的荟萃分析均未显示褪黑激素与安慰剂相比对夜间血压有显著影响。然而，亚组分析显示，控释褪黑激素显着降低夜间血压，而快速释放褪黑激素没有效果。控制释放褪黑激素（-6。
Background: Patients with nocturnal hypertension are at higher risk for cardiovascular complications such as myocardial infarction and cerebrovascular insult. Published studies inconsistently reported decreases in nocturnal blood pressure with melatonin. Methods: A meta-analysis of the efficacy and safety of exogenous melatonin in ameliorating nocturnal blood pressure was performed using a random effects model of all studies fitting the inclusion criteria, with subgroup analysis of fast-release versus controlled-release preparations. Results: Seven trials (three of controlled-release and four of fast-release melatonin) with 221 participants were included. Meta-analysis of all seven studies did not reveal significant effects of melatonin versus placebo on nocturnal blood pressure. However, subgroup analysis revealed that controlled-release melatonin significantly reduced nocturnal blood pressure whereas fast-release melatonin had no effect. Systolic blood pressure decreased significantly with controlled-release melatonin (−6.