Population structure analysis of the Mycobacterium tuberculosis Beijing family indicates an association between certain sublineages and multidrug resistance

Population structure analysis of the Mycobacterium tuberculosis Beijing family indicates an association between certain sublineages and multidrug resistance
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DOI:
10.1128/aac.00579-08
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发表时间:
2008-10-01
影响因子:
4.9
通讯作者:
Wada, Takayuki
Wada, Takayuki
中科院分区:
医学2区
文献类型:
--
作者:
Iwamoto, Tomotada;Yoshida, Shiomi;Wada, Takayuki

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Our population-based study of the Mycobacterium tuberculosis Beijing family examined the frequency of occurrence of each sublineage of this family, classified by using 10 synonymous single-nucleotide polymorphisms. The results revealed the overabundance of two evolutionary sublineages in a population of multidrug-resistant and extensively drug-resistant tuberculosis bacteria.