Chiral Separation of Cationic Drugs on an α1-Acid Glycoprotein Bonded Stationary Phase
Chiral Separation of Cationic Drugs on an α1-Acid Glycoprotein Bonded Stationary Phase
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α1-酸性糖蛋白键合固定相上阳离子药物的手性分离
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
S. Barkan
中科院分区：
文献类型：
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作者：
G. Schill;I. Wainer;S. Barkan
本文报道了一种含有α1-酸性糖蛋白的手性固定相EnantioPac（LKB）对多种重要的手性铵盐化合物的拆分。研究了阳离子、阴离子和中性改性剂在移动的相中对保留和选择性的优化作用。结果表明，溶质保留根据离子对分布模型。对结构差异很大的化合物进行了研究，大多数化合物的分离因子都很高。
Abstract A commercially available chiral stationary phase containing α1-acid glycoprotein on silica (EnantioPac, LKB) was applied to the resolution of a number of pharmacologically important enantiomeric ammonium compounds. The optimization of retention and selectivity by cationic, anionic and neutral modifiers in the mobile phase was studied. The results suggest that the solutes are retained according to an ion-pair distribution model. Compounds of widely different structures were studied, and high separation factors were achieved for a majority.