In search of common developmental and evolutionary origin of the claustrum and subplate
In search of common developmental and evolutionary origin of the claustrum and subplate
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DOI：
10.1002/cne.24922
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发表时间：
2020-05-06
影响因子：
2.5
通讯作者：
Molnar, Zoltan
中科院分区：
文献类型：
--
作者：
Bruguier, Hannah;Suarez, Rodrigo;Molnar, Zoltan
人类屏状核是广泛分布的新皮质连接的主要枢纽，是位于岛叶皮质和纹状体之间的一层薄的、双侧灰质。亚板是一个很大程度上短暂的皮质结构，包含一些最早产生的大脑皮层神经元，并具有重要的发育功能，以建立内和外皮质连接。在人类和猕猴中，一些亚板细胞经历调节性细胞死亡，但一些仍然作为间质白色细胞。在小鼠和大鼠的大脑中，形成了一个致密的层，即层6 b，它保留在皮质下面，与白色物质相邻。啮齿类动物的6 b层是否与灵长类动物的基板或间质白色细胞同源仍有争议。基因表达模式，如Nurr 1/Nr 4a 2的基因表达模式，表明啮齿动物亚板和6 b层和屏状体中的持久亚板细胞可能具有相似的起源。此外，屏状核和第6 b层的出生日期在小鼠中也同样早熟。这些观察结果促使我们推测屏状体和亚板的共同发育和进化起源。在这里，我们系统地比较了目前可用的数据细胞结构，进化起源，基因表达，细胞类型，出生日期，神经发生，谱系和迁移，电路连接，细胞死亡的神经元，有助于屏状核和基板。基于它们的相似性和差异，我们提出了一个部分共同的早期进化起源的细胞，成为屏状体和subplate，一个可能的情况下，在这些细胞群体中共享所有的Aromotes。
The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains some of the earliest generated neurons of the cerebral cortex and has important developmental functions to establish intra- and extracortical connections. In human and macaque some subplate cells undergo regulated cell death, but some remain as interstitial white matter cells. In mouse and rat brains a compact layer is formed, Layer 6b, and it remains underneath the cortex, adjacent to the white matter. Whether Layer 6b in rodents is homologous to primate subplate or interstitial white matter cells is still debated. Gene expression patterns, such as those of Nurr1/Nr4a2, have suggested that the rodent subplate and the persistent subplate cells in Layer 6b and the claustrum might have similar origins. Moreover, the birthdates of the claustrum and Layer 6b are similarly precocious in mice. These observations prompted our speculations on the common developmental and evolutionary origin of the claustrum and the subplate. Here we systematically compare the currently available data on cytoarchitecture, evolutionary origin, gene expression, cell types, birthdates, neurogenesis, lineage and migration, circuit connectivity, and cell death of the neurons that contribute to the claustrum and subplate. Based on their similarities and differences we propose a partially common early evolutionary origin of the cells that become claustrum and subplate, a likely scenario that is shared in these cell populations across all amniotes.