ANALYSIS OF CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY REACTION AND T-CELL PROLIFERATIVE RESPONSE IN ELDERLY NURSING-HOME PATIENTS - AN APPROACH TO IDENTIFYING IMMUNODEFICIENT PATIENTS
ANALYSIS OF CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY REACTION AND T-CELL PROLIFERATIVE RESPONSE IN ELDERLY NURSING-HOME PATIENTS - AN APPROACH TO IDENTIFYING IMMUNODEFICIENT PATIENTS
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DOI：
10.1159/000213203
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发表时间：
1990-07-01
期刊：
影响因子：
3.5
通讯作者：
MAKINODAN, T
中科院分区：
文献类型：
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作者：
CASTLE, SC;NORMAN, DC;MAKINODAN, T
临床经验表明，迟发型超敏反应（DTH）皮肤试验缺乏敏感性，在评估系统性细胞介导的免疫（CMI）的完整性或状态的最近或远程分枝杆菌感染的老年疗养院居民。为了澄清这个问题，DTH反应纯化蛋白衍生物（PPD），破伤风类毒素和白色念珠菌进行了比较，循环胸腺衍生的淋巴细胞（T细胞）增殖（TCP）刺激PPD和抗CD3抗体在24个随机选择的养老院居民。DTH反应和TCP反应之间的DTH反应，但不好的DTH nonreactors，这表明可能有年龄相关的皮肤本身的免疫变化相当好。此外，发现单独对PPD进行DTH皮肤试验是系统性CMI完整性的不良指标。
Clinical experience suggests the delayed-type hypersensitivity (DTH) skin test lacks sensitivity in assessing the integrity of systemic cell-mediated immunity (CMI) or the status of recent or remote mycobacterial infections in elderly nursing home residents. In an attempt to clarify this issue, DTH reaction to purified protein derivative (PPD), tetanus toxoid and Candida albicans was compared with circulating thymus-derived lymphocyte (T cell) proliferation (TCP) to stimulation with PPD and anti-CD3 antibody in 24 randomly selected nursing home residents. The DTH reaction and the TCP response correlated reasonably well among the DTH reactors but poorly among DTH nonreactors, suggesting there may be age-related immunologic changes in the skin itself. Also, the DTH skin test to PPD alone was found to be a poor index of the integrity of systemic CMI.