Correlation of lymphocyte transformation with tuberculin skin-test sensitivity.
Correlation of lymphocyte transformation with tuberculin skin-test sensitivity.
复制标题
淋巴细胞转化与结核菌素皮试敏感性的相关性。
DOI：
10.1164/arrd.1973.107.4.530
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
H. Jones
中科院分区：
文献类型：
--
作者：
S. Miller;H. Jones
本文报告了34例受试者对结核菌素纯蛋白衍生物（PPD）的迟发型超敏反应程度，用一、中、二种不同强度的PPD作序贯皮试，同时用PPD最大限度地激发受试者的淋巴细胞。检测皮试敏感性所需的结核菌素最低强度与淋巴细胞转化指数的对数之间存在线性关系。在34名受试者中的25名中，对任何强度的结核菌素的皮肤试验反应的大小可以在淋巴细胞转化程度的一个标准偏差内预测。与对3种强度结核菌素完全无反应的受试者无淋巴细胞转化相比，在对一定强度PPD表现出1 - 4 mm和5 - 9 mm皮肤试验反应的所有受试者中发生一定程度的淋巴细胞转化，表明大多数皮肤试验反应，无论大小，都具有体外免疫学相关性。这些...
The degree of delayed hypersensitivity to tuberculin purified protein derivative (PPD) was determined in 34 subjects by sequential skin testing with first, intermediate, and second strength PPD, and simultaneously the subjects’ lymphocytes were maximally challenged in vitro with PPD. A linear relationship existed between the minimal strength of tuberculin required to detect skin test sensitivity and the logarithm of the lymphocyte transformation index. in 25 of the 34 subjects, the size of the skin test response to any strength of tuberculin could be predicted within one standard deviation from the degree of lymphocyte transformation. the occurrence of some degree of lymphocyte transformation in all subjects who manifested skin test responses of 1 to 4 mm and 5 to 9 mm to some strength PPD compared to no lymphocyte transformation in subjects completely nonreactive to the 3 strengths of tuberculin suggested that most skin test reactions, regardless of size, have an in vitro, immunologic correlate. These da...