Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease
Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease
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DOI：
10.4269/ajtmh.2007.76.155
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Tesh, Robert B.
中科院分区：
文献类型：
--
作者：
Sbrana, Elena;Xiao, Shu-Yuan;Tesh, Robert B.
1970年在中非发现了首例猴痘（MPX）人类病例。此后，中非和西非出现了零星疫情。2003年，在从西非输入受感染的啮齿动物后，美国发生了人MPX疫情。2003年爆发的临床特征没有中非人中的疾病严重。这种观察到的差异的原因尚不清楚。在这项研究中，临床和病理特征的实验感染与代表性的中非和北美MPX病毒株进行了比较，在地松鼠模型的疾病。结果表明，美国2003年病毒，其遗传学上是西非MPX病毒分支的成员，比中非MPX病毒株毒力低。
The first human cases of monkeypox (MPX) were recognized in central Africa in 1970. Since then, sporadic outbreaks of the disease have occurred in central and west Africa. In 2003, an outbreak of human MPX occurred in the United States after importation of infected rodents from west Africa. Clinical features of the 2003 outbreak were less severe than accounts of the disease among people in central Africa. The reasons for this observed difference are unknown. In this study, the clinical and pathologic characteristics of experimental infection with representative central African and North American MPX virus strains were compared in a ground squirrel model of the disease. The results indicate that the US 2003 virus, which phylogenetically is a member of the west African MPX virus clade, was less virulent than central African MPX virus strains.