Mechanisms underlying the limited injectability of hydraulic calcium phosphate paste
Mechanisms underlying the limited injectability of hydraulic calcium phosphate paste
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DOI：
10.1016/j.actbio.2008.03.004
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发表时间：
2008-09-01
影响因子：
9.7
通讯作者：
Bohner, Marc
中科院分区：
文献类型：
--
作者：
Habib, Mohamed;Baroud, Gamal;Bohner, Marc
磷酸钙（CaP）骨水泥越来越多地用于微创硬组织植入。在最近的一些出版物中，已经讨论和研究了改善水硬性磷酸钙糊剂的不良可注射性的可能方法。然而，液相分离机制，导致有限的可注射性尚未得到解决。液相分离意味着挤出的糊剂的液粉比（LPR）高于留在注射器中的糊剂的LPR。本文的目的是纠正这种情况下，在从注射器通过套管注射糊剂的过程中发生的液相迁移。在实验上，可以看出，注射器糊剂和挤出物两者的液体含量在糊剂注射期间降低。此外，高挤出速度、小注射器尺寸、短套管和高LPR有利于良好的注射性。这些结果可以部分地解释在光的流变学测量进行了调查膏。(C)2008 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Calcium phosphate (CaP) cements are being increasingly used for minimally invasive hard tissue implantation. Possible approaches to improve the bad injectability of hydraulic calcium phosphate pastes have been discussed and investigated in a number of recent publications. However, the liquid-phase separation mechanism leading to the limited injectability has not yet been addressed. Liquid-phase separation means that the liquid-to-powder ratio (LPR) of the extruded paste is higher than the LPR of the paste left in the syringe. The goal of this paper was to remedy this situation by looking at the liquid-phase migration occurring during the injection of a paste from a syringe through a cannula. Experimentally, it was seen that the liquid content of both the syringe paste and the extrudate decreased during the paste injection. Moreover, a high extrusion velocity, small syringe size, short cannula and high LPR favored a good injectability. These results could be partly explained in light of rheological measurements performed with the investigated paste. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.