Altered White Matter Microstructure in Adolescents With Major Depression: A Preliminary Study
Altered White Matter Microstructure in Adolescents With Major Depression: A Preliminary Study
复制标题
DOI：
10.1016/j.jaac.2009.11.005
复制
发表时间：
2010-02-01
影响因子：
13.3
通讯作者：
Lim, Kelvin O.
中科院分区：
文献类型：
--
作者：
Cullen, Kathryn R.;Klimes-Dougan, Bonnie;Lim, Kelvin O.
目的：重度抑郁障碍（MDD）多发于青少年，但青少年抑郁症的神经生物学机制尚不清楚。成人和儿童人群的结构神经影像学研究表明，额叶神经网络与重度抑郁症的病理生理有关。弥散张量成像（DTI）是一种测量白质（WM）微观结构的有前途的工具，用于检查神经连接以及它们如何在MDD中异常。方法：我们采用两种不同的方法来分析MDD青少年（n = 14）与健康志愿者（n = 14）的DTI数据。结果：首先，假设驱动的方法是使用概率束造影来描绘源自亚属前扣带皮层（ACC）的束。青少年MDD表现出较低的分数各向异性（FA）在连接亚一般ACC和杏仁核在右半球的WM束。第二种探索性方法是对FA进行体素比较。该分析揭示了10组MDD青少年在WM束（包括右、左钩带和肩带上）内FA显著低于健康组（未校正）。结论：这些初步数据支持了额叶神经通路WM微结构改变可能参与青少年重度抑郁症病理生理的假设。j。儿童与青少年精神病学,2010;49(2):173 - 183。
Objective: Major depressive disorder (MDD) Occurs frequently in adolescents, but the neurobiology of depression in youth is poorly understood. Structural neuroimaging studies in both adult and pediatric populations have implicated frontolimbic neural networks in the pathophysiology of MDD. Diffusion tensor imaging (DTI), which measures white matter (WM) microstructure, is a promising tool for examining neural connections and how they may be abnormal in MDD. Method: We used two separate approaches to analyze DTI data in adolescents with MDD (n = 14) compared with healthy volunteers (n = 14). Results: The first, hypothesis-driven approach was to use probabilistic tractography to delineate tracts arising from the subgenual anterior cingulate cortex (ACC). Adolescents with MDD demonstrated lower fractional anisotropy (FA) in the WM tract connecting subgenual ACC to amygdala in the right hemisphere. The second, exploratory approach was to conduct a voxelwise comparison of FA. This analysis revealed 10 clusters where adolescents with MDD had significantly lower (uncorrected) FA than the healthy group within WM tracts including right and left uncinate and supragenual cingulum. Conclusions: These preliminary data support the hypothesis that altered WM microstructure in frontolimbic neural pathways may contribute to the pathophysiology of MDD in adolescents. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(2):173-183.