Regulating genes by packaging domains: bits of heterochromatin in euchromatin?
Regulating genes by packaging domains: bits of heterochromatin in euchromatin?
复制标题
通过包装域调节基因：常染色质中的异染色质片段？
DOI：
10.1016/0168-9525(93)90171-d
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Elgin,SC
中科院分区：
文献类型：
--
作者：
Shaffer,CD;Wallrath,LL;Elgin,SC
CHRISTOPHER D. SHAFFER, LORI L. WALLRATH AND SARAH CR ELGIN DEPARTMENT OF BIOLOGY, WASHINGTON UNIVERSITY, Box 1229, ST LOUIS, MO 63130, USA. which a variegating gene is inactivated and the frequency with which it is incorporated within cytologically visible heterochromatin 16, 17, and also by changes at the molecular level in the chromatin structure of variegating loci TM. While there is evidence that some variegating loci are inactivated as a consequence of DNA loss, due to differential replication or DNA elimination 13, 19, it is clear that in many cases of PEV this does not occur 2 m. Inactivation is generally the result of changes in chromatin structure'v'6. One would therefore expect mutations that modify the extent of inactivation at variegating loci to lie in genes encoding chromosomal proteins, their modifiers, or assembly factors (reviewed in Ref. 8). Many of these mutations have been identifieda2, 23, including both suppressors of PEV [Su (var)], which suppress inactivation of the variegating gene, and znhancers of PEV [En (var)], whicil enhance inactivation. Mutations at as many as 120 loci can have a dominant effect on PEV 2"~. Several such modifier loci have been cloned and characterized (reviewed in Refs 8, 25). Interestingly, many
