Role of microRNAs in stroke and poststroke depression.

Role of microRNAs in stroke and poststroke depression.
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DOI:
10.1155/2013/459692
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发表时间:
2013-12-02
影响因子:
--
通讯作者:
Liu XY
Liu XY
中科院分区:
其他
文献类型:
--
作者:
Yan H;Fang M;Liu XY

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微小RNA(miRNA)是一类广泛分布于真核细胞中的非编码RNA,可以通过抑制转录或翻译来调节基因表达。它们参与生长、发育、疾病发生、进展等重要的生理和病理过程。 miRNA 对于神经系统的发育至关重要。近年来的研究表明,一些miRNA在脑卒中等缺血性脑血管疾病的发生和发展中发挥重要作用,也参与脑卒中后抑郁症(PSD)的发生和发展。本文对miRNA在脑缺血和PSD中的作用研究进行综述,其结果可能有助于临床上利用miRNA对脑缺血和PSD进行诊断和预后判断。
microRNAs (miRNA), a sort of noncoding RNAs widely distributed in eukaryotic cells, could regulate gene expression by inhibiting transcription or translation. They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. Recent studies have demonstrated that some miRNAs play important roles in the occurrence and development of ischemic cerebrovascular diseases such as stroke and were also involved in the occurrence and development of poststroke depression (PSD). Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.
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