HISTOMORPHOMETRIC STUDY OF ALVEOLAR BONE TURNOVER IN ORTHODONTIC TOOTH MOVEMENT
HISTOMORPHOMETRIC STUDY OF ALVEOLAR BONE TURNOVER IN ORTHODONTIC TOOTH MOVEMENT
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DOI：
10.1016/8756-3282(91)90029-i
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发表时间：
1991-01-01
期刊：
影响因子：
4.1
通讯作者：
WRONSKI, TJ
中科院分区：
文献类型：
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作者：
KING, GJ;KEELING, SD;WRONSKI, TJ
在大鼠磨牙附近的牙槽骨中测量选定的组织形态计量学参数，用40克倾斜力设计向近中倾斜磨牙，并用假手术进行治疗。分别于术后第1、3、5、7、10、14天取牙及周围组织制作不脱钙矢状面不脱钙切片，进行静态和动态组织形态计量学研究。通过测量不同垂直位置第1天牙周韧带(PDL)宽度的差异，并用线性回归分析将这些差异关联起来，来评估初始牙齿移位。所有参数都是在牙齿周围四个象限(近中-远中；咬合-根尖)附近的牙槽骨中测量的。计算每组中每个参数的平均值和标准误差，并使用方差分析和Scheffe多重比较检验进行成对比较，比较时间和组内特定差异。在假手术组大鼠，骨吸收主要发生在远牙槽表面，但近中和远中表面在骨形成方面没有明显的表面相关差异。在假体的两个表面上，骨吸收的时间效应都不明显。这些发现表明，远中牙槽骨的吸收促进了假手术大鼠的磨牙远中漂移。正畸治疗大鼠牙周韧带宽度变化在牙根近中半部最大，向根尖呈线性衰减，表明牙根表面的咬合半部分发生了较大的初始牙位移。这些位置的牙槽骨转换的组织形态计量学参数也被认为更大，这表明这些突起对牙齿移位的增加很敏感。在正畸治疗的大鼠中，整个牙槽骨以及压力(近)和张力(远)表面都经历了持续四天的吸收波，在此之前经历了两天的激活期，然后是持续到实验结束或实验(14天)的形成波。骨形成和吸收波之间的相对平衡是特定位置的，张力侧的形成占主导地位，压力侧的吸收占主导地位。这些发现与以下结论一致，即压力和张力引发类似的骨转换事件，骨沉积或移除由这些部位发生的骨形成和骨吸收之间的相对量之间的平衡程度控制。
Selected histomorphometric parameters were measured in alveolar bone adjacent to rat molars treated with a 40-gram tipping force designed to tip the molar mesially and with a sham procedure. Undecalcified parasagittal sections of teeth and surrounding tissues were prepared for static and dynamic histomorphometry at 1, 3, 5, 7, 10, and 14 days. Initial tooth displacement was assessed by measuring differences between groups in the widths of the day-1 periodontal ligaments (PDL) at various vertical locations and correlating these using linear regression analysis. All parameters were measured in the alveolar bone adjacent to four quadrants around the teeth (mesial-distal; occlusal-apical). Means and standard errors for each parameter in each group were calculated and compared for time- and group-specific differences using ANOVA and pairwise comparisons with Scheffe's multiple comparison tests. In sham-treated rats, bone resorption predominated on the distal alveolar surface, but significant surface-related differences between mesial and distal surfaces in bone formation were not demonstrated. Time-specific effects in bone resorption were not evident on either surface in the shams. These findings suggested that molar distal drift in the sham rat is facilitated by resorption in the distal alveolar bone. PDL width changes in orthodontically-treated rats were greatest in the mesial occlusal half of the root and decayed linearly toward the apex indicating that the greater initial tooth displacement occurred in the occlusal half of the root surface. Histomorphometric parameters of alveolar bone turnover were also seen to be greater in these locations, suggesting that these processes were sensitive to the increased tooth displacement. In orthodontically-treated rats, the total paradental alveolar bone and both pressure (mesial) and tension (distal) surfaces experienced a wave of resorption that lasted for four days, was preceded by an activation period of two days, and was followed by a wave of formation that persisted until the end or the experiment (14 days). The relative balance between bone formation and resorption waves was location-specific, with formation predominant on the tension side and resorption predominant on the pressure. These findings are consistent with the conclusion that pressure and tension initiate similar bone turnover events, and that bone deposition or removal is controlled by the degree of balance between the relative amounts of bone formation and resorption that occur at these sites.