White matter changes with normal aging
White matter changes with normal aging
复制标题
DOI：
10.1212/wnl.50.4.972
复制
发表时间：
1998-04-01
期刊：
影响因子：
9.9
通讯作者：
Albert, MS
中科院分区：
文献类型：
--
作者：
Guttmann, CRG;Jolesz, FA;Albert, MS
我们用定量MRI评估了72名年龄在18岁到81岁之间的健康志愿者的脑组织区室。颅内白质分数在59岁以上年龄组明显降低。脑脊液分数随着年龄的增长而显著增加，与先前的报道一致。颅内灰质百分比随年龄的增长有所下降，但最年轻受试者与59岁以上受试者之间无显著差异。对高密度体积进行协方差调整并没有改变前述结果。颅内白质体积百分比与脑脊液体积百分比呈正相关。在灰质没有显著减少的情况下，白质随着年龄的增长而显著减少，这一发现与最近人类和非人类灵长类动物的神经病理学报告一致。
We evaluated brain tissue compartments in 72 healthy volunteers between the ages of 18 and 81 years with quantitative MRI. The intracranial fraction of white matter was significantly lower in the age categories above 59 years. The CSF fraction increased significantly with age, consistent with previous reports. The intracranial percentage of gray matter decreased somewhat with age, but there was no significant difference between the youngest subjects and the subjects above 59. A covariance adjustment for the volume of hyperintensities did not alter the foregoing results. The intracranial percentage of white matter volume was strongly correlated with the percentage volume of CSF. The finding of a highly significant decrease with age in white matter, in the absence of a substantial decrease in gray matter, is consistent with recent neuropathologic reports in humans and nonhuman primates.