Prenatal exposure to PM2.5 and Congenital Heart Diseases in Taiwan
Prenatal exposure to PM2.5 and Congenital Heart Diseases in Taiwan
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DOI：
10.1016/j.scitotenv.2018.11.284
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发表时间：
2019-03-10
影响因子：
9.8
通讯作者：
Guo, Yue Leon
中科院分区：
文献类型：
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作者：
Huang, Ching-chun;Chen, Bing-yu;Guo, Yue Leon
暴露于环境空气污染的锗与先天性心脏病（CHD）有关。然而，只有少数研究调查了怀孕早期PM2.5暴露的影响，结果不一致。本研究旨在评估产前暴露于PM2.5与CHD发生之间的关系。我们从台湾出生登记处选择了2007年至2014年期间报告患有CHD的782名新生儿，并使用基于人群的病例对照设计随机选择了4692名无任何出生缺陷的对照。暴露于环境空气污染物，主要是PM2.5，PM10，CO，SO2，NO2，和O-3在怀孕3-8周的数据检索从空气质量监测站和插值到每个乡镇使用普通克里格。我们应用非条件logistic回归模型对潜在混杂因素进行调整，以评估相关性。结果显示，妊娠早期PM2.5暴露增加（校正比值比[aOR]= 1.21，95%置信区间[CI]= 1.03-1.42，每四分位数变化= 13.4 μ g/m3）与总体CHD发生率呈正相关。此外，我们发现房间隔缺损（aOR = 1.43，95% CI = 1.01-2.02）、内膜垫缺损（aOR = 2.37，95% CI= 1.01-5.58）和肺动脉和瓣膜狭窄（aOR = 1.71，95% CI = 1.06-2.78）与PM2.5暴露显著相关。其他空气污染物则没有类似的影响。这项研究表明，在心脏胚胎发育的关键时期，PM2.5暴露增加与某些CHD的发生之间存在一定的正相关。(c)2018爱思唯尔B. V.保留所有权利。
Gestational exposure to ambient air pollution has been associated with Congenital Heart Diseases (CHDs). However, only a few studies, with inconsistent results, have investigated the effects of PM2.5 exposure during early pregnancy. This study aims to evaluate the association between prenatal exposure to PM2.5 and CHDs occurrence. We selected 782 births reported to have CHDs between 2007 and 2014 from the Taiwanese Birth Registry and randomly selected 4692 controls without any birth defects using a population-based case-control design. Data of exposure to ambient air pollutants, mainly PM2.5, PM10, CO, SO2, NO2, and O-3 during weeks 3-8 of pregnancy were retrieved from air quality monitoring stations and interpolated to every township using ordinary kriging. We applied unconditional logistic regression models adjusted for potential confounders to evaluate the associations. The results revealed a positive correlation between increased PM2.5 exposure (adjusted odds ratio [aOR]= 1.21, 95% confidence interval [CI]= 1.03-1.42, per interquartile range change= 13.4 mu g/m(3)) during early pregnancy and overall CHDs occurrence. Furthermore, we found that atrial septal defect (aOR = 1.43, 95% CI = 1.01-2.02), endocardial cushion defect (aOR = 2.37, 95% CI= 1.01-5.58), and pulmonary artery and valve stenosis (aOR = 1.71, 95% CI = 1.06-2.78) were significantly associated with PM2.5 exposures. No similar effects were observed for the other air pollutants. This study has demonstrated some positive associations between increased PM2.5 exposure during the critical period of cardiac embryogenesis and certain CHDs occurrence. (c) 2018 Elsevier B.V. All rights reserved.