ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos
ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos
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DOI：
10.1101/gad.11.13.1651
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发表时间：
1997-07-01
影响因子：
10.5
通讯作者：
Priess, JR
中科院分区：
文献类型：
--
作者：
Page, BD;Zhang, W;Priess, JR
表皮细胞在秀丽隐杆线虫胚胎发生过程中通过几种不同的谱系模式产生。这些模式由决定早期胚胎分裂球身份的母体基因控制。我们表明，胚胎表达的基因elt-1，这是以前所示的编码GATA样转录因子，所需的表皮细胞的生产由这些谱系。根据它们的谱系历史，在野生型胚胎中成为表皮的细胞在elt-1突变胚胎中成为神经元或肌肉细胞。ELT-1蛋白在表皮细胞及其前体中表达。我们建议，elt-1功能在表皮细胞命运的规范的早期步骤。
Epidermal cells are generated during Caenorhabditis elegans embryogenesis by several distinct lineage patterns. These patterns are controlled by maternal genes that determine the identities of early embryonic blastomeres. We show that the embryonically expressed gene elt-1, which was shown previously to encode a GATA-like transcription factor, is required for the production of epidermal cells by each of these lineages. Depending on their lineage history, cells that become epidermal in wild-type embryos become either neurons or muscle cells in elt-1 mutant embryos. The ELT-1 protein is expressed in epidermal cells and in their precursors. We propose that elt-1 functions at an early step in the specification of epidermal cell fates.