Diffusion alterations in corpus callosum of patients with HIV.
Diffusion alterations in corpus callosum of patients with HIV.
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发表时间：
2006-03
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通讯作者：
Ying Wu;P. Storey;B. Cohen;L. Epstein;R. Edelman;A. Ragin
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作者：
Ying Wu;P. Storey;B. Cohen;L. Epstein;R. Edelman;A. Ragin
背景和目的在感染人类免疫缺陷病毒（HIV）的患者的胼胝体和额叶白质中已经发现了弥散性改变，尽管这些发现与认知恶化的相关性尚未确定。这项研究测试了这样的假设：扩散张量成像可以检测感染 HIV 的认知障碍患者这些区域的组织状态变化，并且获得的测量结果与认知障碍的严重程度相关。方法 测定胼胝体（膝部和压部）和额叶白质（FWM）的分数各向异性（FA）和平均扩散率（MD）。对 11 名 HIV 参与者和 11 名对照参与者的 DTI 测量结果进行了比较。通过同时进行的神经学和神经心理学评估的认知状态测量来检查关系模式。结果感染 HIV 的患者压部 FA 值显着降低，并且与痴呆严重程度和运动速度缺陷相关。感染 HIV 的患者压部的 MD 值显着增加，并且与运动速度缺陷相关。 FA 测量值还与视觉记忆（膝）、视觉建构（FWM）和言语记忆（FWM）任务的表现显着相关。结论 HIV感染者的胼胝体压部存在弥散异常，这些改变与痴呆的严重程度和运动速度损失相关。使用定量神经影像对胼胝体完整性进行体内评估可能具有作为 HIV 感染患者脑损伤标志物的潜在用途。
BACKGROUND AND PURPOSE Diffusion alterations have been identified in the corpus callosum and frontal white matter of patients infected with human immunodeficiency virus (HIV), though the relevance of these findings to cognitive deterioration has not yet been determined. This study tested the hypothesis that diffusion tensor imaging can detect tissue status alterations in these regions in cognitively impaired patients infected with HIV and the acquired measurements correlate with the severity of cognitive impairment. METHODS Fractional anisotropy (FA) and mean diffusivity (MD) were determined for corpus callosum (genu and splenium) and frontal white matter (FWM). The DTI measurements were compared in 11 HIV and 11 control participants. Patterns of relationship were examined with cognitive status measures from concurrent neurologic and neuropsychologic evaluations. RESULTS FA values for the splenium were significantly reduced in the patients infected with HIV and correlated with dementia severity and deficits in motor speed. MD values for the splenium were significantly increased in the patients infected with HIV and correlated with deficits in motor speed. FA measurements were also significantly correlated with performance on visual memory (genu), visuoconstruction (FWM), and verbal memory (FWM) tasks. CONCLUSION Diffusion abnormalities were identified in the splenium of the corpus callosum in patients infected with HIV, and these alterations were associated with dementia severity and motor speed losses. In vivo assessment of callosal integrity by using quantitative neuroimaging may have potential utility as a marker of brain injury in patients infected with HIV.