Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.
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C57BL x C3H F1 小鼠诱导肝结节性病变的形态学和转移性质。
DOI：
10.1093/jnci/77.4.951
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发表时间：
1978
期刊：
影响因子：
11.2
通讯作者：
K. Rao
中科院分区：
文献类型：
--
作者：
S. Vesselinovitch;N. Mihailovich;K. Rao
苯并(a)芘、乙基亚硝基脲、联苯胺引起的明确结节性肝脏病变的转移能力。对盐酸和二乙基亚硝胺进行了评价。分别独立评估1264只C57BL/6J x C3HeB/FeJ F1小鼠的编码肝脏和肺组织是否存在原发性结节病变和转移。原发病变根据其大小、细胞形态和生长模式分为增生性、腺瘤性和小梁结节。126只携带增生性结节的小鼠均未发生肺转移。291只腺瘤性结节病变小鼠中有4只（1.4%）出现转移。相比之下，在733只患有小梁型结节病变或合并其他病变的小鼠中，266只（36%）出现肺转移。肺转移首次在51 - 60周龄死亡的小鼠中发现（5%）。这一比率随着死亡年龄的增长而增加，在存活超过81周的小鼠中达到51%。由此得出结论，显示小梁的结节和更多间变性的实片状生长代表了小鼠真正的肝细胞癌。
The metastatic capabilities of well-defined nodular hepatic lesions induced by benzo(a)pyrene, ethylnitrosourea, benzidine.2HCl, and diethylnitrosamine were evaluated. Coded liver and lung tissues from 1264 treated C57BL/6J x C3HeB/FeJ F1 mice were assessed independently for the presence of primary nodular lesions and metastases, respectively. Primary lesions were classified according to their size, cell morphology, and growth patterns into hyperplastic, adenomatous, and trabecular nodules. None of the 126 mice bearing hyperplastic nodules had pulmonary metastases. Four of 291 (1.4%) mice with adenomatous nodular lesions showed metastases. In contrast, of the 733 mice bearing the trabecular type of nodular lesions alone or in combination with other lesions 266 (36%) showed pulmonary metastases. The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%). This rate increased as a function of age at death, reaching an incidence of 51% in mice surviving more than 81 weeks. It was concluded that nodules showing trabecular and the more anaplastic solid sheet type of growths represented bona fide hepatocellular carcinomas in the mouse.