Neuropsychological dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease
Neuropsychological dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease
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DOI：
10.1016/s0887-6177(00)00075-5
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发表时间：
2001-10-01
影响因子：
2.6
通讯作者：
Robbins, MK
中科院分区：
文献类型：
--
作者：
Crews, WD;Jefferson, AL;Robbins, MK
很少有研究探讨与终末期肺病相关的神经心理学后遗症。本文报告了47例终末期慢性阻塞性肺疾病（COPD）患者的神经心理学数据，这些患者被评估为肺移植的潜在候选人。虽然患者表现出多样性的神经认知功能障碍，他们的最高频率的损害被发现在选择性提醒测试（SRT）。具体而言，超过50%的完成SRT的患者表现出受损的即时自由回忆和一致的长期检索缺陷，而超过44%的这些人表现出缺乏长期检索。这些患者中有26%至35%表现出SRT长期存储策略、线索回忆和延迟回忆不足，而超过32%的样本显示入侵错误数量增加。在完成威斯康星州卡片分类测验（WCST）的患者中，超过31%的人未能达到预期的分类数量，而超过23%的人表现出持续错误和总错误的数量增加。在连线测试（TMT）：B部分和韦氏记忆量表-R（WMS-R）视觉再现II子测试中也发现了临床显著的损伤频率（大于样本的20%）。明尼苏达多相人格调查表-2（MMPI-2）人格评估表明，患者正在经历各种各样的躯体主诉，并且他们可能一直在降低效率水平。这些研究结果进行了讨论，根据患者的终末期COPD和可能有助于他们的神经心理测试性能的因素。对临床实践和未来研究的影响也包括在内。(C)2001年美国国家神经心理学学会。出版社：Elsevier Science Ltd
Few studies have examined the neuropsychological sequelae associated with end-stage pulmonary disease. Neuropsychological data are presented for 47 patients with end-stage chronic obstructive pulmonary disease (COPD) who were being evaluated as potential candidates for lung transplantation. Although patients exhibited a diversity of neurocognitive deficits, their highest frequencies of impairment were found on the Selective Reminding Test (SRT). Specifically, over 50% of the patients completing the SRT exhibited impaired immediate free recall and consistent long-term retrieval deficits, while more than 44% of these individuals displayed deficient longterm retrieval. Deficient SRT long-term storage strategies, cued recall, and delayed recall were exhibited by between 26% and 35% of these patients, while more than 32% of this sample displayed elevated numbers of intrusion errors. Over 31% of the patients completing the Wisconsin Card Sorting Test (WCST) failed to achieve the expected number of categories on this measure, while more than 23% of these individuals demonstrated elevated numbers of perseverative errors and total errors. Clinically notable frequencies of impairment (greater than 20% of the sample) were also found on the Trail Making Test (TMT): Part B and the Wechsler Memory Scale-R (WMS-R) Visual Reproduction II subtest. Minnesota Multiphasic Personality Inventory-2 (MMPI-2) personality assessments indicated that patients were experiencing a diversity of somatic complaints and that they may have been functioning at a reduced level of efficiency. These findings are discussed in light of patients' end-stage COPD and factors possibly contributing to their neuropsychological test performances. Implications for clinical practice and future research are also included. (C) 2001 National Academy of Neuropsychology. Published by Elsevier Science Ltd.