A biocompatible titanium headpost for stabilizing behaving monkeys
A biocompatible titanium headpost for stabilizing behaving monkeys
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DOI：
10.1152/jn.00102.2007
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发表时间：
2007-08-01
影响因子：
2.5
通讯作者：
Horton, Jonathan C.
中科院分区：
文献类型：
--
作者：
Adams, Daniel L.;Economides, John R.;Horton, Jonathan C.
许多涉及猴子的神经生理学实验要求在动物执行任务时头部保持稳定。通常，使用由牙科丙烯酸形成的头帽将柱附接到颅骨以实现此目标。我们描述了一个新的headpost，开发的几个原型的细化，并提供一个AutoCAD文件，以帮助在机械车间生产。这个头柱是由一块商业纯钛制成的。它有一个踏板组成的四肢安排在配置的“K”。“这些在手术过程中弯曲，以匹配头骨的曲率，并与专门的钛骨螺钉连接。将头柱植入7只年龄从2岁到成年的恒河猴中。在长达17个月的定期使用后，没有一个被拒绝。他们需要很少或根本不需要每天擦头皮，只在头皮上造成0.80厘米（2）的缺损。植入后的计算机断层扫描显示，颅骨经过重塑，将足板嵌入骨中。两名受试者的尸检证实了这一发现。头骨的外层已经长到钛合金踏板上，而内层已经变厚，以掩埋钛合金螺钉的尖端。通过在头柱上施加越来越大的扭矩，证明了颅骨/植入物结合的显著强度。在26.3 Nm时，头柱从金属踏板上撕裂，但没有螺钉松动。该植入物的优异性能是通过将生物相容性钛整合到重塑骨组织中来解释的。头柱植入更简单，锚定更牢固，更容易维护，并且比丙烯酸连接的器械更不显眼。
Many neurophysiological experiments involving monkeys require that the head be stabilized while the animal performs a task. Often a post is attached to the skull to accomplish this goal, using a headcap formed from dental acrylic. We describe a new headpost, developed by refinement of several prototypes, and supply an AutoCAD file to aid in machine shop production. This headpost is fabricated from a single piece of commercially pure titanium. It has a footplate consisting of four limbs arranged in the configuration of a "K." These are bent during surgery to match the curvature of the skull and attached with specialized titanium bone screws. Headposts were implanted in seven rhesus monkeys ranging in age from 2 yr to adult. None has been rejected after up to 17 mo of regular use. They require little or no daily toilette and create only a 0.80-cm(2) defect in the scalp. Computed tomography after implantation showed that the skull undergoes remodeling to embed the footplate in bone. This finding was confirmed by necropsy in two subjects. The outer table of the skull had grown over the titanium footplate, whereas the inner table had thickened to bury the tips of the titanium screws. The remarkable strength of the skull/implant bond was demonstrated by applying increasing amounts of torque to the headpost. At 26.3 Nm, the headpost tore from its metal footplate, but no screws came loose. The excellent performance of this implant is explained by integration of biocompatible titanium into remodeled bone tissue. The headpost is simpler to implant, more securely anchored, easier to maintain, and less obtrusive than devices attached with acrylic.